Digoxin Produkt Beschreibung

DIGOXIN Struktur
  • CAS-Nr.20830-75-5
  • Bezeichnung:Digoxin
  • Englisch Name:DIGOXIN
  • Synonyma:Digoxin
  • CBNumber:CB2407221
  • Summenformel:C41H64O14
  • Molgewicht:780.94
  • MOL-Datei:20830-75-5.mol
Digoxin physikalisch-chemischer Eigenschaften

DIGOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R25:Giftig beim Verschlucken.
    R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  • Chemische Eigenschaften White Crystalline Powder
  • Verwenden Cardiotonic
  • Verwenden cardiac stimulant
  • Definition ChEBI: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
  • Trademarks Lanoxin (GlaxoSmithKline).
  • Allgemeine Beschreibung Digitalis (Crystodigin) is isolated fromD. lanata and D. purpurea among other Digitalis spp., and isthe chief active glycoside in digitalis leaf, with 1 mg digitoxinequal to 1 g of digitalis leaf therapy. In patients who missdoses, digitalis is very useful for maintenance therapy becauseof the longer half-life it provides. The longer durationand increased half-life are a result of the lack of the C-12hydroxy that is present in digoxin. In digoxin, this hydroxyplays two roles: (a) it serves as a site for metabolism, whichreduces the compound’s half-life; and (b) it gives more hydrophiliccharacter, which results in greater water solubilityand ease in renal elimination.
  • Allgemeine Beschreibung Digoxin (Lanoxin) is a purified digitalis preparationfrom D. lanata and represents the most widely useddigitalis glycoside. This wide use is primarily a result of itsfast onset and short half-life. Position 3 of the steroid is substitutedwith three digitoxose residues that, when removed,provide a genin or aglycone steroid that is still capable of receptorbinding but with altered pharmacokinetics.
  • Allgemeine Beschreibung Clear to white crystals or white crystalline powder. Odorless. Used as a cardiotonic drug.
  • Health Hazard Material is a digitalis glycoside. Ingestion can cause death. Material is considered super toxic; probable human oral lethal dose is less than 5 mg/kg, a taste (less than 7 drops) for a 70 kg (150 lb.) person. Persons at risk include those taking drugs for thyroid and renal diseases. Quinidine and diuretics taken concurrently with DIGOXIN can be hazardous. It should be used with extreme care during pregnancy and in nursing mothers.
  • Brandgefahr Avoid light.
  • Sicherheitsprofil A deadly poison by most routes. Human systemic effects by ingestion: anorexia, cardlac arrhythmias, nausea and vomiting, visual field changes, pulse rate decrease, fall in blood pressure. An experimental teratogen. When heated to decomposition it emits acrid and irritating fumes. See also DIGITALIS.
  • läuterung methode Crystallise digoxin from aqueous EtOH, aqueous pyridine, EtOH/CHCl3, and dry it in a vacuum at 100o. The melting point depends on heating rate, but when placed in a bath at 260o and heated slowly it decomposes at 265o. In EtOH it has max at 220nm ( 12,800). [Smith J Chem Soc 508 1930, X-ray: Go et al. Cryst Struct Commun 8 149, 1031 1979, Beilstein 18/4 V 381.] HIGHLY TOXIC.
DIGOXIN Upstream-Materialien And Downstream Produkte
Downstream Produkte
Digoxin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
20830-75-5, DIGOXIN Verwandte Suche:
  • Digoxin 20830-75-5
  • (3beta,5beta,12beta)-3-((o-2,6-dideoxy-beta-d-ribo-hexapyranosyl-(1-4)-2,6-dide
  • -12,14-dihydroxycard-20(22)-enolide
  • 14-dihydroxy-,(3beta,5beta,12beta)-xopyranosyl)oxy]-1
  • 14-dihydroxy-,(3beta,5beta,12beta)-y)-1
  • -2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.)-2,6-dideoxy-beta-d-ribo-he
  • dixina
  • dokim
  • dynamos
  • homolle’sdigitalin
  • lanatilin
  • lanicor
  • lanocardin
  • lanoxicaps
  • lenoxicaps
  • lenoxin
  • longdigox
  • neodioxanin
  • oxy-beta-d-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)
  • rougoxin
  • saroxin
  • sk-digoxin
  • stillacor
  • Purgoxin
  • Toloxin
  • Vanoxin
  • Card-20(22)-enolide, 3-[(O-2,6-dideoxy-- D-ribo-hexopyranosyl-(1<<FAR)-O-2,6-dideoxy- -D-ribo-hexopyranosyl-(1<<FAR)-2,6-dideoxy- -D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3,5,12)-
  • hexopyranosyl)oxy]-12,14-dihydroxy-,(3β,5β,12β)-
  • (3,5,12)-3-[(O-2,6-Dideoxy--D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy--D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy--D-ribo-hexopyranosyl)oxyl]-12,14-dihydroxycard-20(22)-enolide
  • 12β-Hydroxydigitoxin, Digoxin
  • digitaline cristallise
  • digitoxine
  • (3beta,5beta,12beta)-3-((O-2,6-Dideoxy-beta-D-ribo-hexapyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxycard-20(22)-enolide
  • 12β,14β-Dihydroxy-5β-carda-20(22)-enolide-3β-yl 4-O-[4-O-(2,6-dideoxy-β-D-altropyranosyl)-2,6-dideoxy-β-D-altropyranosyl]-2,6-dideoxy-β-D-altropyranoside
  • 3β-[[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β,14β-card-20(22)-enolide
  • 3β-[4-O-[4-O-(2,6-Dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β,14β-carda-20(22)-enolide
  • Digohan
  • Digoxin,95%
  • (3beta,5beta,12beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxyl]-12,14-dihydroxycard-20(22)-enolide
  • Digoxin (250 mg)
  • Methanol (Test Digoxin, 1.0 mg/mL)
  • Digoxin 96%
  • (3β,5β,12β)- 3-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide
  • Digoxin solution
  • Digoxin, >=98%
  • 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one
  • acygoxin
  • card-20(22)-enolide,3-((o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1-4)-o-2,6-di
  • card-20(22)-enolide,3-[(o-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.fwdarw.)-o
  • cardoxin