Card-20(22)-enolid-,3-((O-4-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1=>4)-O-2,6-di-deoxy-beta-D-ribo-hexopyranosyl-(1=>4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-di-hydroxy-,(3 beta, 5 beta,12 beta)-

Bezeichnung:Card-20(22)-enolid-,3-((O-4-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1=>4)-O-2,6-di-deoxy-beta-D-ribo-hexopyranosyl-(1=>4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-di-hydroxy-,(3 beta, 5 beta,12 beta)-

CAS-Nr5355-48-6

Englisch Name:BETA-ACETYLDIGOXIN

CBNumberCB4328012

SummenformelC43H66O15

Molgewicht822.98

MOL-Datei5355-48-6.mol

Synonyma

Card-20(22)-enolid, 3-[(O-4-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-

Card-20(22)-enolid-,3-((O-4-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1=>4)-O-2,6-di-deoxy-beta-D-ribo-hexopyranosyl-(1=>4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-di-hydroxy-,(3 beta, 5 beta,12 beta)-

Schmelzpunkt	271-273°C
alpha	D20 +30.4° (c = 1.2 in alc)
Siedepunkt	681.03°C (rough estimate)
Dichte	1.1139 (rough estimate)
Brechungsindex	1.5940 (estimate)
storage temp.	-20°C Freezer
Löslichkeit	Practically insoluble in water, sparingly soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
pka	13.41±0.70(Predicted)

Sicherheit

RIDADR	3249
HazardClass	6.1(a)
PackingGroup	II

Gefahreninformationscode (GHS)

BETA-ACETYLDIGOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Originator
Novodigal ,Asta Medica Arzneimittel
Verwenden
Digoxin derivative, a cardiotonic glycosides
Definition
ChEBI: Acetyldigoxin is a cardenolide glycoside.
Manufacturing Process
Dried crude product of the partial acetylation of digoxin (42 g) prepared from digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400 ml) is added to the solution with stirring. Fine crystals, which begin to separate immediately, are left at room temperature for 5 hours, then they are filtered with suction, washed with n-hexane and dried in vacuum at 40°C, yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added thereto with stirring. The crystals, which separate after standing for 6 hours at room temperature, are filtered, washed with toluene and ether and dried in vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C.
The filtrate, which results from the separation of product 1, is evaparated to dryness in vacuum. The residue, which mainly contains unreacted digoxin, is purified by recrystallization from pyridine/ether/water (3.5:5:40) and repeatedly acetylated. It can then be recycled to produce more β- acetyldigoxin. The filtrate resulting from the separation of product 2 is evaporated to dryness. The resulting residue contains the di- and polyacetyl derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled to produce more β-acetyldigoxin. Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and dicyclohexylcarbodiimide using the last one as a condensing agent.
Therapeutic Function
Cardiotonic

BETA-ACETYLDIGOXIN Upstream-Materialien And Downstream Produkte

Card-20(22)-enolid-,3-((O-4-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1=>4)-O-2,6-di-deoxy-beta-D-ribo-hexopyranosyl-(1=>4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-di-hydroxy-,(3 beta, 5 beta,12 beta)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5355-48-6, BETA-ACETYLDIGOXIN Verwandte Suche:

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