3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid

Bezeichnung:3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid

CAS-Nr630-60-4

Englisch Name:G-STROPHANTHIN

CBNumberCB6753829

SummenformelC29H44O12

Molgewicht584.66

MOL-Datei630-60-4.mol

Synonyma

3-(6-Desoxy-α-L-mannopyranosyloxy)-1,5,11a,14,19-pentahydroxycard-20(22)-enolid

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid physikalisch-chemischer Eigenschaften

Schmelzpunkt	200°C
Siedepunkt	561.69°C (rough estimate)
Dichte	1.1941 (rough estimate)
Brechungsindex	-32 ° (C=1, H2O)
storage temp.	Desiccate at -20°C
Löslichkeit	H₂O: 10 mg/mL cold
Aggregatzustand	powder
pka	13.04±0.70(Predicted)
Farbe	white
Wasserlöslichkeit	13g/L(25 ºC)
Merck	6901
Stabilität	Hygroscopic
EPA chemische Informationen	Ouabain (630-60-4)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/25-33
S-Sätze:	45
RIDADR	UN 1544 6.1/PG 1
WGK Germany	3
RTECS-Nr.	RN3850000
F	8
Giftige Stoffe Daten	630-60-4(Hazardous Substances Data)
Toxizität	LD50 oral in guinea pig: 8280ug/kg

Gefahreninformationscode (GHS)

G-STROPHANTHIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/25:Giftig beim Einatmen und Verschlucken.
R33:Gefahr kumulativer Wirkungen.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
One of several cardiac glycosides that have been used clinically as cardiotonic agents and diuretics. Ouabain is obtained from the seeds of Strophanthus gratus, Acokanthera ouabaio, and related species. It was formerly prescribed under the name strophanthuis as the purified seed extract.
Chemische Eigenschaften
Ouabain is a white crystalline solid.
Verwenden
Ouabain is a Na+/K+-ATPase inhibitor hormone, which negatively modulates allergic airway inflammation induced by ovalbumin (OVA).
Definition
ChEBI: Ouabain is a steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor, an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor, an EC 2.3.3.1 [citrate (Si)-synthase] inhibitor, an EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor, a plant metabolite, a cardiotonic drug, an ion transport inhibitor and an anti-arrhythmia drug. It is a cardenolide glycoside, a steroid hormone, an alpha-L-rhamnoside, a 14beta-hydroxy steroid, a 5beta-hydroxy steroid and an 11alpha-hydroxy steroid. It is a conjugate acid of an ouabain(1-).
Allgemeine Beschreibung
Odorless, white crystals or crystalline powder as an octahydrate. Used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
Reaktivität anzeigen
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate) [EPA, 1998].
Health Hazard
G-STROPHANTHIN is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
Brandgefahr
When heated to decomposition, G-STROPHANTHIN emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (G-STROPHANTHIN octahydrate)
Biologische Aktivität
Selective Na + , K + -ATPase inhibitor.
Sicherheitsprofil
Poison by ingestion, intramuscular, intraperitoneal, intravenous, subcutaneous, and parented routes. Moderately toxic by intraduodenal route. A cardac stimulant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes
mögliche Exposition
Ouabain, similar to digitoxin, is used to produce rapid digitalization in acute congestive heart failure. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter; enzyme inhibitor.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Lager
-20°C (desiccate)
Versand/Shipping
UN1544 Alkaloids, solid, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
läuterung methode
It crystallises from water as the octahydrate. Dry it at 130o. It decomposes at 190o when dry. Store it in the dark as it is light sensitive, but it is stable in air. Its solubility (g/100mL) in H2O is 1.3 (~25o), 20 (~100o), and in EtOH it is 1.0 (~25o) and 12.5 (~78o). It is highly TOXIC as it is an inhibitor of cation transport and of Na+ and K+ ATPase. [Beilstein 18/5 V 625.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.).

G-STROPHANTHIN Upstream-Materialien And Downstream Produkte

3-(6-Desoxy-alpha-L-mannopyranosy-loxy)-1,5,11a,14,19-pentahydroxy-card-20(22)-enolid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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