Convallatoxin

Bezeichnung:Convallatoxin

CAS-Nr508-75-8

Englisch Name:CONVALLATOXIN

CBNumberCB4190741

SummenformelC29H42O10

Molgewicht550.64

MOL-Datei508-75-8.mol

Synonyma

Convallatoxin

Convallatoxin physikalisch-chemischer Eigenschaften

Schmelzpunkt	238-239℃ (water )
alpha	D22 -1.7 ± 3° (c = 0.65 in methanol); D25 -9.4 ± 3° (c = 0.72 in dioxane)
Siedepunkt	542°C (rough estimate)
Dichte	1.41±0.1 g/cm3 (20 ºC 760 Torr)
Brechungsindex	1.5376 (estimate)
storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
pka	13.04±0.70(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Merck	13,2538
Stabilität	Hygroscopic

Sicherheit

RIDADR	3249
WGK Germany	2
RTECS-Nr.	GL4025000
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	508-75-8(Hazardous Substances Data)
Toxizität	LD50 in mice, rats (mg/kg): 10.0 i.p., 16.0 i.v. (Frster)

Gefahreninformationscode (GHS)

CONVALLATOXIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Convallatoxin,C-Strong Co., Ltd.
Verwenden
Convallatoxin is a cardenolide that is used in the treatment of congestive heart failure. It may also be used in the treatment of tumor cells at nanomolar concentrations due to its anti-proliferative effects
Definition
ChEBI: A cardenolide glycoside that consists of strophanthidin having a 6-deoxy-alpha-L-mannopyranosyl (L-rhamnosyl) group attached at position 3.
Manufacturing Process
1 part of grinded flowers Convallaria majalis and 12 parts of water was stirred for 15 hours at ambient temperature. After a filtration and washing with water, a clear brown filtrate was mixed with a concentrate solution of lead acetate. A lead consisted precipitate was filtered off and sodium phosphate was added to filtrate for removing the remaining lead. The solution was filtered again and 0.5 - 0.6 parts of a coal was added and the mixture was stirred for 3 hours at ambient temperature. The coal was filtered off, washed with a little water and dried at 30°-40°C. A hot CHCl3 was added to dry coal adsorbent. CHCl3 was distilled off to dryness in vacuum. The residue was dissolved in a little methanol and the obtained solution was shook 3 times with 2 volumes of petrol ether and then distilled to dryness in vacuum. This product was dissolved in minimum absolute ethanol and added to 10 volumes of dry ether. The formed precipitate was filtered and washed with ether to
give the glycoside as a gray powder. It was crystallized from diluted ethanol as colorless needles.
Therapeutic Function
Cardiotonic
läuterung methode
Crystallise convallatoxin from EtOAc, CHCl3/EtOH (9:1) or MeOH/Et2O. The tetraacetate has m 238-242o (from MeOH/Et2O), [] D 25 -5o (CHCl3). [Reyle et al. Helv Chim Acta 33 1541 1950, Fieser & Jacobson J Am Chem Soc 59 2335 1937 Beilstein 1 8 III/IV 3142.]

CONVALLATOXIN Upstream-Materialien And Downstream Produkte

Convallatoxin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

508-75-8, CONVALLATOXIN Verwandte Suche:

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