7H-Furo[3,2-g][1]benzopyran-7-on

Bezeichnung:7H-Furo[3,2-g][1]benzopyran-7-on

CAS-Nr66-97-7

Englisch Name:Psoralen

CBNumberCB3181900

SummenformelC11H6O3

Molgewicht186.16

MOL-Datei66-97-7.mol

Synonyma

7H-Furo[3,2-g][1]benzopyran-7-on

7H-Furo[3,2-g][1]benzopyran-7-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	160-162 °C
Siedepunkt	280.64°C (rough estimate)
Dichte	1.2477 (rough estimate)
Brechungsindex	1.6310 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	65.16mg/L(25 ºC)
maximale Wellenlänge (λmax)	328nm(EtOH)(lit.)
Merck	14,7928
BRN	152784
InChIKey	ZCCUUQDIBDJBTK-UHFFFAOYSA-N
LogP	1.670
CAS Datenbank	66-97-7(CAS DataBase Reference)
NIST chemische Informationen	7H-furo[3,2-g][1]benzopyran-7-one(66-97-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26
WGK Germany	3
RTECS-Nr.	LV0944000
F	8-10
HS Code	29339900
Giftige Stoffe Daten	66-97-7(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Psoralen Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Psoralens are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.
Verwenden
Use as photochemical probe in biological systems
Verwenden
As photochemical probe in biological systems: P.-S. Song, C.-N. Ou, Ann. N.Y. Acad. Sci. 346, 355 (1980).
Definition
ChEBI: The simplest member of the class of psoralens that is 7H-furo[3,2-g]chromene having a keto group at position 7. It has been found in plants like Psoralea corylifolia and Ficus salicifolia.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 6735, 1984 DOI: 10.1021/ja00334a044
Synthetic Communications, 37, p. 63, 2007 DOI: 10.1080/00397910600978093
Biochem/physiol Actions
Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Psoralen Upstream-Materialien And Downstream Produkte

7H-Furo[3,2-g][1]benzopyran-7-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

66-97-7, Psoralen Verwandte Suche:

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