9-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-on

Bezeichnung:9-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-on

CAS-Nr2009-24-7

Englisch Name:XANTHOTOXOL

CBNumberCB9438695

SummenformelC11H6O4

Molgewicht202.16

MOL-Datei2009-24-7.mol

Synonyma

9-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-on

9-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	250°C
Siedepunkt	428.1±45.0 °C(Predicted)
Dichte	1.526±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	5.74±0.20(Predicted)
Farbe	Light Beige to Dark Brown
LogP	1.405 (est)

Sicherheit

R-Sätze:	25
S-Sätze:	20-45-24/25
RIDADR	2810
HS Code	29329990

Gefahreninformationscode (GHS)

XANTHOTOXOL Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S20:Bei der Arbeit nicht essen und trinken.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC₅₀s = 23.59 and 15.57 μM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC₅₀ = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.
Chemische Eigenschaften
Dark Brown Solid
Verwenden
A hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been shown to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent studies show that it may also have antioxidant and anticancer activities.
Verwenden
Xanthotoxol is a hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been show n to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent stud ies show that it may also have antioxidant and anticancer activities.
Definition
ChEBI: Xanthotoxol is an 8-hydroxyfurocoumarin.
Synthesis Reference(s)
Synthetic Communications, 37, p. 361, 2007 DOI: 10.1080/00397910601038616

XANTHOTOXOL Upstream-Materialien And Downstream Produkte

9-Hydroxy-7H-furo[3,2-g][1]benzopyran-7-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2009-24-7, XANTHOTOXOL Verwandte Suche:

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