Xanthotoxin Produkt Beschreibung

8-Methoxypsoralen Struktur
298-81-7
  • CAS-Nr.298-81-7
  • Bezeichnung:Xanthotoxin
  • Englisch Name:8-Methoxypsoralen
  • Synonyma:9-Methoxyfuro[3,2-g]chromen-7-on;Xanthotoxin
    8-MP;8-MOP;Dermox;Uvadex;Vitpso;Ammodin;Metoxin;Puvalen;Puvamet;Meloxine
  • CBNumber:CB6733540
  • Summenformel:C12H8O4
  • Molgewicht:216.19
  • MOL-Datei:298-81-7.mol
Xanthotoxin physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :148-150 °C(lit.)
  • Siedepunkt: :276.6°C (rough estimate)
  • Dichte :1.1344 (rough estimate)
  • Brechungsindex :1.4270 (estimate)
  • storage temp.  :-20°C Freezer, Under Inert Atmosphere
  • Löslichkeit :H2O: slightly soluble
  • Aggregatzustand :Needle-Like Crystals or Powder
  • Farbe :white to yellow
  • Wasserlöslichkeit :PRACTICALLY INSOLUBLE
  • Merck  :14,5988
  • BRN  :196453
  • CAS Datenbank :298-81-7(CAS DataBase Reference)
  • NIST chemische Informationen :Methoxsalen(298-81-7)
  • EPA chemische Informationen :7H-Furo[3,2-g][1] benzopyran-7-one, 9-methoxy-(298-81-7)
Sicherheit

8-Methoxypsoralen Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R43:Sensibilisierung durch Hautkontakt möglich.
    R46:Kann vererbbare Schäden verursachen.
    R45:Kann Krebs erzeugen.
    R34:Verursacht Verätzungen.
  • S-Sätze Betriebsanweisung: S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften White to cream-colored, crystalline solid; odorless. Slightly soluble in alcohol; practically insoluble in water. Combustible.
  • Verwenden antipsoriatic, pigmentation agent
  • Verwenden Naturally occurring analog of Psoralen (P839800). Use in treatment of psoriasis and mycosis fungoides.
  • Verwenden For the treatment of psoriasis and vitiligo
  • Verwenden Naturally occurring analog of psoralen. Use in treatment of psoriasis and mycosis fungoides
  • Verwenden A potent suicide inhibitor of cytochrome P-450.
  • Definition ChEBI: A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
  • Trademarks 8-Mop (Valeant); Oxsoralen (Valeant); Uvadex (Therakos).
  • Allgemeine Beschreibung Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.
  • Air & Water Reaktionen Sensitive to light and air. Insoluble in water.
  • Reaktivität anzeigen 8-Methoxypsoralen is incompatible with strong oxidizing agents.
  • Brandgefahr Flash point data for 8-Methoxypsoralen are not available; however, 8-Methoxypsoralen is probably combustible.
  • Kontakt-Allergie This fur(an)ocoumarin is an phototoxic compound that causes phototoxic dermatitis. Many plants of the Apiaceae–Umbelliferae and most of the Rutaceae family contain 5-methoxypsoralen and 8-methoxypsoralen. Their spectra is in the UVA range (300–360 nm). It is used in combination with UVA to treat various skin disorders such as psoriasis.
  • Sicherheitsprofil Confirmed carcinogen. Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. A drug used to treat slun diseases.
  • läuterung methode Purify xanthotoxin by recrystallisation from *C6H6/pet ether (b 60-80o) to give silky needles, or from EtOH/Et2O to give rhombic prisms or from hot H2O to give needles. It is soluble in aqueous alkali due to ring opening of the cyclic lactone but recyclises upon acidification. It has UV max in EtOH at 219, 249 and 300nm (log  4.32, 4.35 and 4.06) and 1H NMR in CDCl3 with at 7.76 (d, 1H, J 10 Hz), 7.71 (d, 1H, J 2.5 Hz), 7.38 (s, 1H), 6.84 (d, 1H, J 2.5 Hz), 6.39 (d, 1H, J 10 Hz) and 4.28 (s, 3H)ppm. [Nore & Honkanen J Heterocycl Chem 17 985 1980.] It is a DNA intercalator, is used in the treatment of dermal diseases, and is a human carcinogen [Tessman et al. Biochemistry 24 1669 1985.] [Beilstein 19 I 711, 19/6 V 15.]
8-Methoxypsoralen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Xanthotoxin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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298-81-7, 8-Methoxypsoralen Verwandte Suche:
  • 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
  • 5-Benzofuranacrylicacid,6-hydroxy-7-methoxy-,δ-lactone
  • 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid gamma-lactone
  • 6-hydroxy-7-methoxy-5-benzofuranacrylicaciddelta-lactone
  • 6-hydroxy-7-methoxy-5-benzofuranacrylicacidelta-lactone
  • 7-Furocoumarin
  • 7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-
  • 7H-Furo[3,2-g][1]benzopyran-7-one,9-methoxy-
  • 8-methoxy-(furano-3’.2’:6.7-coumarin)
  • 8-Methoxy-[furano-3'.2':6.7-coumarin]
  • 8-methoxy[furano-3’,2’:6,7-coumarin]
  • Ammodin
  • geroxalen
  • Meladinin
  • Meladinine
  • Meladoxen
  • Meloxine
  • Methoxa-Dome
  • Methoxalen
  • Methoxaten
  • methoxsalen[qr]
  • NCI-C55903
  • New-Meladinin
  • Oxoralen
  • oxoralen-ultra
  • oxsoralan
  • Oxsoralen
  • Oxsoralen lotion
  • oxsoralenultra
  • Oxsoralen-ultra
  • Methoxsalen USP
  • XANTHOTOXIN, FOR FLUORESCENCE
  • 8-Methoxypsoralan
  • XANTHOTOXIN(P)
  • XANTHOTOXIN(RG)
  • 9-METHOXYFURO(3,2-G)BENZOPYRAN-7-ONE
  • METHOXASALEN / 99% / XANTHOTOXIN
  • 8-Methoxypsoralen (Xanthotoxin)
  • 9-Methoxy-7H-furo[3,2-γ],[1]benzopyran-7-one
  • 8-Methoxy-6,7-(vinyleneoxy)-2H-1-benzopyran-2-one
  • Dermox
  • Metoxin
  • 8-METHOXYPSOLAREN(METHOXSALEN)
  • 8-Methoxypsoralen,99%
  • 8-MOP, 9-Methoxyfuro[3,2-g][1]benzopyran-7-one, Ammoidin, Methoxsalen, Xanthotoxin
  • Methoxsale
  • Methoxsalen (500 mg)
  • 8-Methoxypsoralen ,98%
  • Methoxsalen|Methoxsalen
  • Methoxsalen (200 mg)
  • Methoxsalen/8-Methoxypsoralen
  • Methoxsalen (Oxsoralen)
  • 8-Methoxypsoralen, 99% 5GR
  • 6-Hydroxy-7-Methoxy-5-benzofuranacrylic Acid δ-Lactone
  • Deltapsoralen
  • 8-Methoxypsoralen 298-81-7
  • 2-g)(1)benzopyran-7-one,9-methoxy-7h-furo(
  • 2-g][1]benzopyran-7-one,9-methoxy-7h-furo[