Enalaprilat

Bezeichnung:Enalaprilat

CAS-Nr76420-72-9

Englisch Name:Enalaprilat

CBNumberCB3163049

SummenformelC18H24N2O5

Molgewicht348.39

MOL-Datei76420-72-9.mol

Synonyma

Enalaprilat

Enalaprilat physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-151°C
alpha	D -67.0° (0.1M HCl)
Siedepunkt	601.0±55.0 °C(Predicted)
Dichte	1.286±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Very slightly soluble or slightly soluble in water, sparingly soluble in methanol, practically insoluble in acetonitrile.
pka	pKa 2.30 (Uncertain);3.39 (Uncertain)
Wasserlöslichkeit	Soluble in water with heating (~60°C)
CAS Datenbank	76420-72-9(CAS DataBase Reference)
EPA chemische Informationen	L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl- (76420-72-9)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	2

Gefahreninformationscode (GHS)

Enalaprilat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Enalaprilat is the diacid active metabolite of enalapril. As an injectable ACE inhibitor, it is reportedly useful in the treatment of uncomplicated accelerated hypertension and hypertensive emergencies. Enalaprilat is more effective in reducing blood pressure in the elderly than in the young, despite the fact that renin activity is lower in old age.
Chemische Eigenschaften
White Crystalline Solid
Originator
Merck (USA)
Verwenden
Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.
Verwenden
primary hypertension
Verwenden
Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor
Definition
ChEBI: Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension an heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is g ven by intravenous injection, usually as the dihydrate.
Trademarks
Vasotec (Biovail);Renitec.

Enalaprilat Upstream-Materialien And Downstream Produkte

Enalaprilat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

76420-72-9, Enalaprilat Verwandte Suche:

Send Inquriy