cis-4-Hydroxy-L-prolin

Bezeichnung:cis-4-Hydroxy-L-prolin

CAS-Nr618-27-9

Englisch Name:cis-4-Hydroxy-L-proline

CBNumberCB6158895

SummenformelC5H9NO3

Molgewicht131.13

MOL-Datei618-27-9.mol

Synonyma

cis-4-Hydroxy-L-prolin

cis-4-Hydroxy-L-prolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	257 °C (dec.) (lit.)
alpha	-59 º (c=2, H2O)
Siedepunkt	242.42°C (rough estimate)
Dichte	1.3121 (rough estimate)
Brechungsindex	-59 ° (C=2, H2O)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	soluble
Aggregatzustand	Powder
pka	2.14±0.40(Predicted)
Farbe	White to beige
Wasserlöslichkeit	soluble
Merck	14,4840
BRN	81440
InChIKey	PMMYEEVYMWASQN-IMJSIDKUSA-N
CAS Datenbank	618-27-9(CAS DataBase Reference)
EPA chemische Informationen	L-Proline, 4-hydroxy-, (4S)- (618-27-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25-36/37/39-27-26
WGK Germany	3
F	10
TSCA	Yes
HS Code	29339900

Gefahreninformationscode (GHS)

cis-4-Hydroxy-L-proline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White to beige powder
Verwenden
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A.
Verwenden
Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
Verwenden
cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.
Definition
ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration).
Biochem/physiol Actions
cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

cis-4-Hydroxy-L-proline Upstream-Materialien And Downstream Produkte

cis-4-Hydroxy-L-prolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

618-27-9, cis-4-Hydroxy-L-proline Verwandte Suche:

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