Oxaceprol

Bezeichnung:Oxaceprol

CAS-Nr33996-33-7

Englisch Name:Oxaceprol

CBNumberCB2482503

SummenformelC7H11NO4

Molgewicht173.17

MOL-Datei33996-33-7.mol

Synonyma

Oxaceprol

Oxaceprol physikalisch-chemischer Eigenschaften

Schmelzpunkt	132-133 °C (dec.)(lit.)
alpha	-119 º (c=4 in H2O)
Siedepunkt	303.8°C (rough estimate)
Dichte	1.3346 (rough estimate)
Dampfdruck	0Pa at 20℃
Brechungsindex	1.4490 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	DMSO : ≥ 32 mg/mL (184.79 mM)
Aggregatzustand	Crystalline Powder
pka	3.48±0.40(Predicted)
Farbe	White
Optische Aktivität	[α]20/D 119°, c = 4 in H2O
Merck	14,6903
BRN	84043
InChIKey	BAPRUDZDYCKSOQ-RITPCOANSA-N
LogP	-1.51 at 20℃
CAS Datenbank	33996-33-7(CAS DataBase Reference)
EPA chemische Informationen	L-Proline, 1-acetyl-4-hydroxy-, (4R)- (33996-33-7)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	41
S-Sätze:	26-36
WGK Germany	3
F	10
TSCA	Yes
HS Code	29339900

Gefahreninformationscode (GHS)

Oxaceprol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White powder
Originator
Jonctum,Merrell,France,1970
Verwenden
trans-1-Acetyl-4-hydroxy-L-proline can be used:
- In the stereospecific synthesis of 4-fluoroglutamic acid.
- To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
- As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).
Manufacturing Process
16.7 g (0.127 mol) of L-hydroxyproline are dissolved in 400 ml of pure boiling acetic acid. With vigorous boiling and agitation, a mixture of 13.7 ml (0.154 mol) of rectified acetic anhydride and 250 ml of pure acetic acid is added during 25 minutes. Without discontinuing the stirring, contents of the flask are cooled by simply causing fresh air to circulate externally round the flask until the temperature of the mixture is reduced to about 35°C. The acetic acid is removed by using a rotary evaporator without exceeding 35°C under a vacuum of about 15 mm Hg. After one hour, 20 ml of anhydrous toluene are added, then 10 ml of anhydrous acetone; the mixture is homogenized and concentrated again as above during 30 minutes. Then 25 ml of acetone are added again, and subsequently 20 ml of toluene, the product being concentrated again; gradually the solution is converted into an amber-colored crystallized paste. Finally, 30 ml of acetone are added to the residue, and stirring is carried out until the oily fraction surrounding the crystals is dissolved. The product is then cooled in an ice chamber, centrifuged, washed with anhydrous acetone and eventually dried, After recrystallization from acetone, crystals are obtained, melting point 132°C.
Therapeutic Function
Antirheumatic
Flammability and Explosibility
Not classified

Oxaceprol Upstream-Materialien And Downstream Produkte

Oxaceprol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

33996-33-7, Oxaceprol Verwandte Suche:

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