alpha,alpha-Diphenyl-4-piperidinomethanol

Bezeichnung:alpha,alpha-Diphenyl-4-piperidinomethanol

CAS-Nr115-46-8

Englisch Name:alpha,alpha-Diphenyl-4-piperidinomethanol

CBNumberCB3146211

SummenformelC18H21NO

Molgewicht267.37

MOL-Datei115-46-8.mol

alpha,alpha-Diphenyl-4-piperidinomethanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	160-163 °C
Siedepunkt	410.55°C (rough estimate)
Dichte	1.0449 (rough estimate)
Dampfdruck	0Pa at 25℃
Brechungsindex	1.5100 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	Chloroform, Methanol (Slightly, Sonicated)
pka	13.32±0.29(Predicted)
Aggregatzustand	Solid
Farbe	White to light beige
InChIKey	ZMISODWVFHHWNR-UHFFFAOYSA-N
CAS Datenbank	115-46-8(CAS DataBase Reference)
NIST chemische Informationen	Azacyclonol(115-46-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	24/25
WGK Germany	WGK 3 highly water endangering
RTECS-Nr.	TN0470000
HS Code	29333999

Gefahreninformationscode (GHS)

alpha,alpha-Diphenyl-4-piperidinomethanol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.
Chemische Eigenschaften
α,α-Diphenyl-4-piperidinemethanol has the appearance of a white to almost white powder to crystals with a melting point of 163 °C. Store at -20 °C.
Originator
Frenquel,Merrell,US,1955
Verwenden
Anxiolytic;H1 antagonist
Verwenden
α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.
Definition
ChEBI: Diphenyl(4-piperidinyl)methanol is a diarylmethane.
Manufacturing Process
A mixture of 26 g (0.1 mol) of α-(4-pyridyl)-benzhydrol, 1.5 g of platinum oxide, and 250 ml of glacial acetic acid is shaken at 50-60°C under hydrogen at a pressure of 40-50 lb/in2. The hydrogenation is complete in 2 to 3 hours. The solution is filtered and the filtrate evaprated under reduced pressure. The residue is dissolved in a mixture of equal parts of methanol and butanone and 0.1 mol of concentrated hydrochloric acid is added. The mixture is cooled and filtered to give about 30 g of α-(4-piperidyl)benzhydrol hydrochloride, MP 283- 285°C, as a white, crystalline substance.
The free base is readily obtained from the hydrochloride salt by treatment with ammonia and when so obtained has a melting point of 160-161°C.
Trademarks
Frenquel (Marion Merrell Dow).
Therapeutic Function
Tranquilizer

alpha,alpha-Diphenyl-4-piperidinomethanol Upstream-Materialien And Downstream Produkte

alpha,alpha-Diphenyl-4-piperidinomethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

115-46-8, alpha,alpha-Diphenyl-4-piperidinomethanol Verwandte Suche:

Send Inquriy