1-(3,4-Difluorphenyl)ethan-1-on

Bezeichnung:1-(3,4-Difluorphenyl)ethan-1-on

CAS-Nr369-33-5

Englisch Name:3',4'-Difluoroacetophenone

CBNumberCB3130786

SummenformelC8H6F2O

Molgewicht156.13

MOL-Datei369-33-5.mol

Synonyma

1-(3,4-Difluorphenyl)ethan-1-on

1-(3,4-Difluorphenyl)ethan-1-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	19-20 °C(lit.)
Siedepunkt	94-95 °C13 mm Hg(lit.)
Dichte	1.246 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.4916(lit.)
Flammpunkt	167 °F
storage temp.	Sealed in dry,Room Temperature
Aggregatzustand	powder to lump to clear liquid
Farbe	White or Colorless to Light yellow
Wichte	1.246
Wasserlöslichkeit	INSOLUBLE
BRN	2206856
InChI	1S/C8H6F2O/c1-5(11)6-2-3-7(9)8(10)4-6/h2-4H,1H3
InChIKey	VWJSSJFLXRMYNV-UHFFFAOYSA-N
SMILES	CC(=O)c1ccc(F)c(F)c1
CAS Datenbank	369-33-5(CAS DataBase Reference)
NIST chemische Informationen	3',4'-Difluoroacetophenone(369-33-5)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
HazardClass	IRRITANT
HS Code	29147000
Speicherklasse	10 - Combustible liquids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

3',4'-Difluoroacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
clear yellowish liquid after melting
Verwenden
3′,4′-Difluoroacetophenone may be used in chemical synthesis.
Definition
ChEBI: 1-(3,4-Difluorophenyl)ethan-1-one is an aromatic ketone.
Synthese

367-11-3

75-36-5

369-33-5

Anhydrous aluminum trichloride (117 g) was slowly added to a mixed solution of 1,2-difluorobenzene (50 g) with acetyl chloride (86 g) at room temperature. The formed slurry was heated to 30°C with continuous stirring. Upon completion of the reaction, the red reaction mixture was cooled to 20 °C and subsequently slowly poured into 800 g of ice-water mixture with continued stirring for 30 min. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 500 ml). All organic phases were combined and washed sequentially with water (2 x 500 ml), saturated sodium bicarbonate solution (2 x 500 ml) and 15% brine (2 x 500 ml), followed by drying with anhydrous sodium sulfate. The organic phases were concentrated to remove the solvent and finally distilled under reduced pressure to collect the fractions at 95 °C/13 mmHg to give 3',4'-difluoroacetophenone (51 g).
Einzelnachweise
[1] Journal of Fluorine Chemistry, 1980, vol. 15, p. 245 - 252
[2] Journal of the Indian Chemical Society, 1982, vol. 59, # 2, p. 293 - 294
[3] Heterocycles, 1981, vol. 16, # 9, p. 1545 - 1553
[4] Journal of Medicinal Chemistry, 1979, vol. 22, # 11, p. 1385 - 1389
[5] Heterocycles, 1981, vol. 16, # 1, p. 71 - 76

3',4'-Difluoroacetophenone Upstream-Materialien And Downstream Produkte

1-(3,4-Difluorphenyl)ethan-1-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

369-33-5, 3',4'-Difluoroacetophenone Verwandte Suche:

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