O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphat

Bezeichnung:O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphat

CAS-Nr57018-04-9

Englisch Name:Tolclofos-methyl

CBNumberCB2451996

SummenformelC9H11Cl2O3PS

Molgewicht301.13

MOL-Datei57018-04-9.mol

Synonyma

O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphat

O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphat physikalisch-chemischer Eigenschaften

Schmelzpunkt	78-80°C
Siedepunkt	338.5±52.0 °C(Predicted)
Dichte	1.401±0.06 g/cm3(Predicted)
Dampfdruck	1.84 x 10^-3 (Pa 25 °C)
Flammpunkt	>100 °C
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly)
Aggregatzustand	Solid
Wasserlöslichkeit	1.10 mg l^-1 (25 °C)
Farbe	White to off-white
Merck	13,9587
BRN	2136521
InChIKey	OBZIQQJJIKNWNO-UHFFFAOYSA-N
LogP	4.560
CAS Datenbank	57018-04-9(CAS DataBase Reference)
NIST chemische Informationen	Phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester(57018-04-9)
EPA chemische Informationen	Tolclofos-methyl (57018-04-9)

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	43-50/53
S-Sätze:	22-24/25-61-60-37-24
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS-Nr.	TF0460000
HS Code	29201900
Giftige Stoffe Daten	57018-04-9(Hazardous Substances Data)
Toxizität	LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami)

Gefahreninformationscode (GHS)

Tolclofos-methyl Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.
Verwenden
Agricultural fungicide.
Definition
ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.
Stoffwechselwegen
Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.
Degradation
[¹⁴C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at pH 5, 7 and 9 at 22°C with DT₅₀ values of 139, 417 and 238 days, respectively. Higher temperature led to a more rapid hydrolysis and two hydrolysis products were detected. O-Demethylation and oxidative desulfuration were the major reactions to yield 2,6-dichloro-p-tolyl methyl hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop- tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation with DT₅₀ values of 44 days (in distilled water), 15-28 days (in natural river and pond water) and less than 2 days in 2% acetone/water. The major degradation reactions included oxidative desulfuration to yield compound 3 and O-demethylation to yield compound 2. The major photodegradation products in river and pond waters and soil thinlayer surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6- dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984). In acetone solution, demethylation of the isomerisation product [2,6- dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop- tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl dihydrogen phosphate (8) as the major photodegradates (Mikami et al., 1984).
Toxicity evaluation
Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).

Tolclofos-methyl Upstream-Materialien And Downstream Produkte

O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57018-04-9, Tolclofos-methyl Verwandte Suche:

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