2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid

Bezeichnung:2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid

CAS-Nr62-51-1

Englisch Name:METHACHOLINE CHLORIDE

CBNumberCB2316248

SummenformelC8H18ClNO2

Molgewicht195.69

MOL-Datei62-51-1.mol

Synonyma

Methacholinchlorid

2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid

2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	171-173 °C(lit.)
Dichte	1.1028 (rough estimate)
Brechungsindex	1.5790 (estimate)
storage temp.	-20°C
Löslichkeit	H₂O: 50 mg/mL, clear, colorless
Aggregatzustand	powder
Farbe	White to Almost white
PH	3.0~7.0 (50g/l, 25℃)
Wasserlöslichkeit	almost transparency
Merck	14,5940
BRN	4162373
Stabilität	Unstable - moisture sensitive. Incompatible with oxidizing agents.
InChI	1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
InChIKey	JHPHVAVFUYTVCL-UHFFFAOYSA-M
SMILES	[Cl-].CC(C[N+](C)(C)C)OC(C)=O
LogP	-3.957 (est)
CAS Datenbank	62-51-1
EPA chemische Informationen	1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	BR5250000
F	3-10-21
TSCA	TSCA listed
HS Code	2923900090
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

METHACHOLINE CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
colourless to white crystalline powder with a slight
Verwenden
Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.
Verwenden
antihypertensive, antianginal
Definition
ChEBI: Methacholine chloride is a quaternary ammonium salt. It contains a methacholine.
Allgemeine Beschreibung
Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.
Biochem/physiol Actions
Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.
Clinical Use
Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.
läuterung methode
It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]

METHACHOLINE CHLORIDE Upstream-Materialien And Downstream Produkte

2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminiumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

62-51-1, METHACHOLINE CHLORIDE Verwandte Suche:

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