ACETYL-DL-CARNITINE HYDROCHLORIDE Struktur

(±)-(2-Acetoxy-3-carboxypropyl)trimethylammoniumchlorid

Bezeichnung:(±)-(2-Acetoxy-3-carboxypropyl)trimethylammoniumchlorid

CAS-Nr2504-11-2

Englisch Name:ACETYL-DL-CARNITINE HYDROCHLORIDE

CBNumberCB5440058

SummenformelC9H18ClNO4

Molgewicht239.7

MOL-Datei2504-11-2.mol

Synonyma

(±)-(2-Acetoxy-3-carboxypropyl)trimethylammoniumchlorid

(±)-(2-Acetoxy-3-carboxypropyl)trimethylammoniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	181 - 183°C
storage temp.	-20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble to 100 mM in water
Stabilität	Hygroscopic
CAS Datenbank	2504-11-2(CAS DataBase Reference)

Sicherheit

WGK Germany	3
RTECS-Nr.	BP2979200

ACETYL-DL-CARNITINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
(±)-Acetylcarnitine Chloride is a drug absorption-enhancing agent in the gastrointestinal tract.
Biologische Aktivität
(±)-acetylcarnitine chloride is an agonist for cholinergic.acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-acetylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3].
Biochem/physiol Actions
Weak cholinergic receptor agonist; intermediate in lipid metabolism.
läuterung methode
Recrystallise the chloride from isopropanol. Dry it over P2O5 under high vacuum. The S-betaine crystallises from EtOH/Et2O with m 145o(dec) and is hygroscopic; it has [] D -19.5o (c 6, H2O). [Krimberg & Wittandt Biochem Z 251 231 1932, Strack et al. Z Physiol Chem 238 191 1936, Beilstein 4 III 1630, 1632.]

(±)-(2-Acetoxy-3-carboxypropyl)trimethylammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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