Furan-2-carbonsure

Bezeichnung:Furan-2-carbonsure

CAS-Nr88-14-2

Englisch Name:2-Furoic acid

CBNumberCB2189363

SummenformelC5H4O3

Molgewicht112.08

MOL-Datei88-14-2.mol

Synonyma

Furan-2-carbonsure

Furan-2-carbonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	−2 °C(lit.)
Siedepunkt	173-174 °C(lit.)
Dichte	1.324 g/mL at 25 °C(lit.)
Dampfdruck	13.732Pa at 25℃
Brechungsindex	n20/D 1.531(lit.)
Flammpunkt	185 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	37g/l
Aggregatzustand	Fine Crystalline Powder
pka	3.16(at 25℃)
Farbe	Off-white to beige
Geruch (Odor)	odorless
Geruchsart	odorless
Wasserlöslichkeit	36 g/L (20 ºC)
Merck	14,4307
BRN	110149
InChIKey	SMNDYUVBFMFKNZ-UHFFFAOYSA-N
LogP	0.628 at 25℃
CAS Datenbank	88-14-2(CAS DataBase Reference)
NIST chemische Informationen	2-Furancarboxylic acid(88-14-2)
EPA chemische Informationen	2-Furancarboxylic acid (88-14-2)

Sicherheit

Kennzeichnung gefährlicher	C,Xi
R-Sätze:	34-36/37/38
S-Sätze:	26-36/37/39-45-36-37/39
RIDADR	UN 3265 8/PG 2
WGK Germany	3
RTECS-Nr.	LV1763000
F	10-19-21
TSCA	Yes
HS Code	29321900

Gefahreninformationscode (GHS)

2-Furoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Aussehen Eigenschaften
C5H4O3; Brenzschleimsäure, alpha-Furoesäure. Leicht gelb-braunes Pulver.
Gefahren für Mensch und Umwelt
Reizt die Atmungsorgane, Augen und die Haut.
Nicht mit starken Oxidationsmitteln in Berührung bringen.
Schutzmaßnahmen und Verhaltensregeln
Schutzhandschuhe als kurzzeitiger Staubschutz.
Verhalten im Gefahrfall
Vorsichtig trocken aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Kohlendioxid, Wasser.
Brennnbar.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 15 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft. Arzt hinzuziehen.
Nach Verschlucken: Reichlich Wasser trinken lassen. Erbrechen wegen Perforationsgefahr vermeiden. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Wässrige Lösung der Substanz mit Natriumhydroxid neutralisieren, zu den wässrigen, neutralen Lösemittelabfällen geben.
Beschreibung
2-Furoic acid is an organic compound, consisting of a furan ring and a carboxylic acid side-group. Along with other furans, its name is derived from the Latin word furfur, meaning bran, from which these compounds were first produced. The salts and esters of furoic acids are known as furoates. 2-Furoic acid is most widely encountered in food products as a preservative and a flavouring agent, where it imparts a sweet, earthy flavour.
Chemische Eigenschaften
white to light yellow crystal powder. 1g is dissolved in 26ml cold water or 4ml boiling water, easily soluble in ethanol and ether. Sublimation at 130-140°C (6.65-8kPa).
Verwenden
2-Furoic acid is an heterocyclic carboxylic acid that is widely used in food products as a preservative and flavouring agent. It is also used in the synthesis of methylfuran, furoamide and furoic acid esters and salts. In the plastics industry, it can be used as plasticizer, thermosetting resin, etc. substitute for chloropicrin in disinfecting grain elevators.
Application
2-Furoic acid (FA) is a preservative, acting as a bactericide and fungicide. Some of the applications of 2-furoic acid include:
Synthesis of a single-molecule magnet, Mn11Gd2 based high-nuclearity heterometallic complex.
Synthesis of orally active antidiabetic vanadyl complex, bis(α-furancarboxylato)oxovanadium(IV).
As a ligand in the synthesis of luminescent 4f-3d heterometallic one-dimensional coordination polymers.
Synthesis of biocompatible multifunctional dextran furoate nanospheres.
FA is often used as a starting material for the production of furoate esters.
FA and its derivatives are also used in the production of nylons principally applied in biomedical researches.
Definition
ChEBI: 2-furoic acid is a furoic acid having the carboxylic acid group located at position 2. It has a role as an inhibitor, a human xenobiotic metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite and a bacterial xenobiotic metabolite. It is a conjugate acid of a 2-furoate.
synthetische
2-furoic acid can be synthesized by the oxidation of furfural. The reaction was carried out at 45°C with vigorous stirring. The reactant is filtered to recover the catalyst copper oxide, the filtrate is acidified with 50% sulfuric acid to pH 3-2.5, suction filtered, washed with water, and dried to obtain 2-furoic acid.
Biologische Funktion
2-Furoic acid was shown to effectively lower serum cholesterol and serum triglyceride levels significantly in rats with an elevation of HDL cholesterol level at 20 mg/kg/day orally. 2-furoic acid appears to interfere directly with the activity of intracellular enzymes rather than affecting high affinity-mediated lipoprotein membrane receptors. In vivo, treatment with 2-furoic acid led to a reduction in the liver and small intestine ATP-dependent citrate lyase, acetyl CoA synthetase, acyl CoA cholesterol acyl transferase, sn-glycerol 3-phosphate acyl transferase, phosphatidylate phosphohydrolase, and heparin induced lipoprotein lipase activities. 2-Furoic acid reduced biliary cholesterol levels, but the agent increased bile salts, which are lithogenic. Acute toxicity studies in mice suggest that the agent has some hepatic toxicity effects. The LD50 was relatively low at 250 mg/kg IP in mice[1].
Hazard
Strong irritant to eyes and skin.
Flammability and Explosibility
Not classified
läuterung methode
Crystallise the acid from hot water (charcoal), dry it at 120o for 2hours, then recrystallise it from CHCl3, and again dry it at 120o for 2hours. For use as a standard in volumetric analysis, good quality commercial acid should be crystallised from CHCl3 and dried as above or sublimed at 130-140o/50-60mm or less. [Beilstein 18 I 438, 18 II 265, 18 III/IV 3914, 18/6 V 102.]
Einzelnachweise
[1] Iris H. Hall. “Hypolipidemic Effects of 2-Furoic Acid in Sprague-Dawley Rats.” Archiv der Pharmazie 326 1 (1993): 15–23.

2-Furoic acid Upstream-Materialien And Downstream Produkte

Furan-2-carbonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

88-14-2, 2-Furoic acid Verwandte Suche:

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