9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Struktur

9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate

Bezeichnung:9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate

CAS-Nr206184-49-8

Englisch Name:9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate

CBNumberCB1855342

SummenformelC9H16N5O5P

Molgewicht305.23

MOL-Datei206184-49-8.mol

9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	270-274oC
storage temp.	2-8°C
Löslichkeit	Aqueous Acid (Slightly), DMSO (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic

Sicherheit

HS Code

2933599550

Gefahreninformationscode (GHS)

9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
WHITE POWDER SOLID
Verwenden
antineoplastic, thymidylate synthase inhibitor
Verwenden
Tenofovir Monohydrate is an HIV-1 RT inhibitor and antiretroviral drug.
Definition
ChEBI: A hydrate that is the monohydrate form of anhydrous tenovir.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tenofovir is a nucleotide analog reverse transcriptase inhibitor, and is widely used as an antiretroviral agent, for the treatment of HIV infection.
Biologische Aktivität
tenofovir hydrate is an inhibitor of reverse transcriptase used for the treatment of the human immunodeficiency virus 1(hiv-1) and hepatitis b [1].tenofovir hydrate is an antiviral pro-drug and the class of nucleoside reverse transcriptase inhibitor. in addition, tenofovir hydrate has been reported to have a dependent relation between intracellular the drug concentrations and prevent function of hiv-1infection with ec50 values of 29 fmol/106, 40 fmol/106 , 77 fmol/106 and 411 fmol/106 cells for inoculum size 1, 5, 20 and 100 respectively. and the ec90 values of tenofovir hydrate are 267 fmol/106, 348 fmol/106, 640 fmol/106 and 2866 fmol/106 cells for virus inoculums size 1, 5, 20 and 100, respectively [1].
Einzelnachweise
[1] duwal s1, schütte c, von kleist m.pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against hiv-1 infection. plos one. 2012;7(7):e40382. doi: 10.1371/journal.pone.0040382. epub 2012 jul 11.

9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

206184-49-8, 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Verwandte Suche:

Send Inquriy