Trimethylphosphit

Bezeichnung:Trimethylphosphit

CAS-Nr121-45-9

Englisch Name:Trimethyl phosphite

CBNumberCB7100684

SummenformelC3H9O3P

Molgewicht124.08

MOL-Datei121-45-9.mol

Synonyma

Trimethylphosphit

Phosphorigs?uretrimethylester

Trimethoxyphosphin

Trimethylphosphit physikalisch-chemischer Eigenschaften

Schmelzpunkt	−78 °C(lit.)
Siedepunkt	111-112 °C(lit.)
Dichte	1.052 g/mL at 25 °C(lit.)
Dampfdichte	4.3 (vs air)
Dampfdruck	17 mm Hg ( 20 °C)
Brechungsindex	n20/D 1.408(lit.)
Flammpunkt	82 °F
storage temp.	2-8°C
Löslichkeit	Chloroform, DMSO (Sparingly)
Aggregatzustand	Liquid
Farbe	Colorless
Wichte	1.052
Explosionsgrenze	5.2-61.2%(V)
Wasserlöslichkeit	Hydrolyzes with water.
Sensitive	Air & Moisture Sensitive
Hydrolytic Sensitivity	4: no reaction with water under neutral conditions
BRN	956570
Expositionsgrenzwerte	TLV-TWA 10 mg/m³ (2 ppm) (ACGIH).
Stabilität	Moisture Sensitive
CAS Datenbank	121-45-9(CAS DataBase Reference)
NIST chemische Informationen	Phosphorous acid, trimethyl ester(121-45-9)
EPA chemische Informationen	Trimethyl phosphite (121-45-9)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F,Xi
R-Sätze:	10-22-36/37/38-41-37/38-65-48/23/24/25-11-46-45-67-66-36
S-Sätze:	26-39-62-45-16-53
RIDADR	UN 2329 3/PG 3
OEB	B
OEL	TWA: 2 ppm (10 mg/m3)
WGK Germany	1
RTECS-Nr.	TH1400000
F	10-13-21
Selbstentzündungstemperatur	250 °C
TSCA	Yes
HS Code	2920 23 00
HazardClass	3
PackingGroup	III
Giftige Stoffe Daten	121-45-9(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: 1600 mg/kg LD50 dermal Rabbit 2600 mg/kg

Gefahreninformationscode (GHS)

Trimethyl phosphite Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT STECHENDEM GERUCH.
CHEMISCHE GEFAHREN
Beim Verbrennen Bildung giftiger Rauche mit Phosphin. Reagiert mit Wasser unter Bildung von Methanol und Dimethylphosphit. Reagiert mit Oxidationsmitteln und starken Basen. Reagiert mit Magnesiumperchlorat unter Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 2 ppm (als TWA) ; (ACGIH 2005).
MAK: IIb (nicht festgelegt, aber Informationen vorhanden) Hautresorption; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann sehr schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt stark die Augen und die Haut. Der Dampf reizt die Atemwege.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Tierversuche zeigen, dass die Substanz möglicherweise fruchtbarkeitsschädigend oder entwicklungsschädigend wirken kann.
LECKAGE
Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.
R-Sätze Betriebsanweisung:
R10:Entzündlich.
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Trimethyl phosphite is a colorless liquid. Distinctive pungent, pyridine-like odor. The Odor Threshold is 0.0001 ppm.
Verwenden
Trimethyl phosphite has been used primarily as an intermediate in the manufacture of pesticides and the synthesis of organophosphate insecticides. It is also used as a fire retardants in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst.
Definition
ChEBI: Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. It has a role as an alkylating agent.
Vorbereitung Methode
Produced via a reaction between phosphorus trichloride and methanol in the presence of a tertiary amine catalyst such as diethylaniline.
Reaktionen
The reaction of trimethyl phosphite and dimethyl acetylenedicarboxylate in the presence of dimedone as the proton source/nucleophile leads to 2-(dimethoxy-phosphoryl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-succinic acid dimethyl ester in 91 % yields.
It reacts with a catalytic amount of methyl iodide in the Arbuzov reaction to give dimethyl methylphosphonate:
P(OCH3)3 → CH3P(O)(OCH3)2
It is susceptible to oxidation to trimethyl phosphate.
Allgemeine Beschreibung
Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in water. Vapors heavier than air. It is used in making pesticides, flame retardants and organophosphorous additives.
Air & Water Reaktionen
Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC).
Reaktivität anzeigen
As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).
Health Hazard
Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.
LD50 value, oral (rats): 1600 mg/kg
Teratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite.
The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..
Brandgefahr
Special Hazards of Combustion Products: Toxic fumes of PO x
Sicherheitsprofil
Moderately toxic by ingestion and skin contact. An experimental teratogen. A severe skin and eye irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use water, foam, fog, CO2. Violent explosive reaction on contact with magnesium perchlorate or trimethyl platinum(IV) azide tetramer. When heated to decomposition it emits toxic fumes of POx. An intermediate in the production of pesticides, fire retardants, and organic phosphorus additives. See also ESTERS.
mögliche Exposition
Trimethyl phosphite is a flame retardant, and used as an intermediate in the manufacture of a number of pesticides, and organophosphorus additives.
Carcinogenicity
Trimethyl phosphite was genotoxic in mouse lymphoma assays but was not mutagenic in various bacterial assays.
Versand/Shipping
UN2329 Trimethyl phosphite, Hazard Class: 3; Labels: 3-Flammable liquid.
läuterung methode
Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]
Inkompatibilitäten
Vaor May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Violent reaction with magnesium perchlorate. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Reacts (hydrolyzes) with water. Incompatible with air, moisture.
Waste disposal
Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.

Trimethyl phosphite Upstream-Materialien And Downstream Produkte

Trimethylphosphit Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

121-45-9, Trimethyl phosphite Verwandte Suche:

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