Hexamethylphosphorsaeuretriamid Produkt Beschreibung

Hexamethylphosphoramide Struktur
680-31-9
  • CAS-Nr.680-31-9
  • Bezeichnung:Hexamethylphosphorsaeuretriamid
  • Englisch Name:Hexamethylphosphoramide
  • Synonyma:Hexamethylphosphorsaeuretriamid;Hexamethylphosphoramid;Hexamethylphosphamid;HMPT;Hempa
    HPT;HMPA;HMPTA;HEMPA;ent50882;ENT 50882;ent50,882;HMPT/HMPA;ENT 50,882;hexamethyl
  • CBNumber:CB1177006
  • Summenformel:C6H18N3OP
  • Molgewicht:179.2
  • MOL-Datei:680-31-9.mol
Hexamethylphosphorsaeuretriamid physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :7 °C (lit.)
  • Siedepunkt: :230-232 °C/740 mmHg (lit.)
  • Dichte :1.03 g/mL at 25 °C (lit.)
  • Dampfdichte :6.18 (vs air)
  • Dampfdruck :0.07 mm Hg ( 25 °C)
  • Brechungsindex :n20/D 1.459(lit.)
  • Flammpunkt: :222 °F
  • storage temp.  :Inert atmosphere,Room Temperature
  • pka :4.69±0.70(Predicted)
  • Aggregatzustand :liquid
  • Farbe :Colorless to light yellow liquid
  • Geruch (Odor) :Spicy odor (no threshold data)
  • Wasserlöslichkeit :Miscible
  • FreezingPoint  :7℃
  • Merck  :14,4725
  • BRN  :1099903
  • Stabilität: :Stable. Incompatible with strong acids, strong oxidizing agents.
  • InChIKey :GNOIPBMMFNIUFM-UHFFFAOYSA-N
  • CAS Datenbank :680-31-9(CAS DataBase Reference)
  • NIST chemische Informationen :N,N,N',N',N",N'-Hexamethylphosphorotriamide(680-31-9)
  • IARC :2B (Vol. 15, Sup 7, 71) 1999
  • EPA chemische Informationen :Hexamethylphosphoramide (680-31-9)
Sicherheit
  • Kennzeichnung gefährlicher :T
  • R-Sätze: :45-46
  • S-Sätze: :53-45-99
  • RIDADR  :2810
  • WGK Germany  :3
  • RTECS-Nr. :TD0875000
  • F  :8
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29299090
  • Giftige Stoffe Daten :680-31-9(Hazardous Substances Data)
  • Toxizität :LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)

Hexamethylphosphoramide Chemische Eigenschaften,Einsatz,Produktion Methoden

  • ERSCHEINUNGSBILD FARBLOSE, BEWEGLICHE FLüSSIGKEIT.
  • CHEMISCHE GEFAHREN Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger Rauche mit Phosphoroxiden, Stickstoffoxiden.
  • ARBEITSPLATZGRENZWERTE TLV: Hautresorption Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
    MAK: Hautresorption; Krebserzeugend Kategorie 2; (DFG 2005).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation und über die Haut.
  • INHALATIONSGEFAHREN Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Möglich sind Auswirkungen auf Lunge, Nieren und Zentralnervensystem mit nachfolgenden Funktionsstörungen und Depression.
  • WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION Möglich sind Auswirkungen auf Atemwege, Nieren und Knochenmark. Möglicherweise krebserzeugend für den Menschen. Kann zu genetischen Schäden führen.
  • LECKAGE Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.
  • R-Sätze Betriebsanweisung: R45:Kann Krebs erzeugen.
    R46:Kann vererbbare Schäden verursachen.
  • S-Sätze Betriebsanweisung: S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  • Chemische Eigenschaften colourless or light amber liquid with an aromatic spicy odour
  • Chemische Eigenschaften Hexamethylphosphoric triamide is a colorless liquid with a spicy odor.
  • Verwenden Aprotic solvent in organic synthesis. Solvent for polymers, gases; polymerization catalyst; thermal stabilizer in polystyrene; protective additive for polyvinyl and polyolefin resins against uv light degradation. De-icing additive for jet fuels. Chemosterilant for a number of insect pests; chemical mutagen.
  • Verwenden Solvent for polymers; polymerization catalyst; stabilizer against thermal degradation in polystyrene; UV stabilizer in polyvinyl and polyolefin resins
  • Allgemeine Beschreibung Clear colorless to light amber liquid with a spicy odor.
  • Air & Water Reaktionen Water soluble.
  • Reaktivität anzeigen Hexamethylphosphoramide may react with strong oxidizing agents and strong acids . Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
  • Hazard Possible carcinogen. Toxic by skin contact. Combustible.
  • Health Hazard The acute toxicity of hexamethylphosphoramide is low. HMPA can cause irritation upon contact with the skin and eyes. Hexamethylphosphoramide has been found to cause cancer in laboratory animals exposed by inhalation and meets the criteria for classification as an OSHA "select carcinogen." Chronic exposure to HMPA can cause damage to the lungs and kidneys. Reproductive effects in male animals treated with hexamethylphosphoramide have been observed. HMPA should be regarded as a substance with poor warning properties.
  • Brandgefahr Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.
  • Brandgefahr Hexamethylphosphoramide is combustible.
  • Flammability and Explosibility Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.
  • mögliche Exposition Hexamethylphosphoric triamide is a material possessing unique properties and is widely used as a solvent in small quantities, in organic and organometallic reactions in laboratories. This is the major source of occu pational exposure to HMPA in the United States. It is also used as a processing solvent in the manufacture of aramid fibers. HMPA has been evaluated for use as an ultraviolet light absorber or inhibitor in polyvinylchloride formulations; as an additive for antistatic effects; as a flame retardant; and as a deicing additive for jet fuels. Hexamethylphosphoric triamide has also been extensively investigated as an insect chemosterilant.
  • Carcinogenicity Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
  • Lager this compound should be handled only in a fume hood, using appropriate impermeable gloves and splash goggles to prevent skin and eye contact. Containers of this substance should be stored in secondary containers.
  • Versand/Shipping UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required
  • läuterung methode The industrial synthesis is usually by treatment of POCl3 with excess of dimethylamine in isopropyl ether. Impurities are water, dimethylamine and its hydrochloride. It is purified by refluxing over BaO or CaO at about 4mm pressure in an atmosphere of nitrogen for several hours, then distilled from sodium at the same pressure. The middle fraction (b ca 90o) is collected, refluxed over sodium under reduced pressure under nitrogen and distilled. It is kept in the dark under nitrogen, and stored in solid CO2. It can also be stored over 4A molecular sieves. Alternatively, it is distilled under vacuum from CaH2 at 60o and is crystallised twice in a cold room at 0o, seeding the liquid with crystals obtained by cooling in liquid nitrogen. After about two-thirds are frozen, the remaining liquid is drained off [Fujinaga et al. Pure Appl Chem 44 117 1975]. For tests of purity see Fujinaga et al. in Purification of Solvents, Coetzee Ed., Pergamon Press, Oxford, 1982. For efficiency of desiccants in drying HMPA see Burfield and Smithers [J Org Chem 43 3966 1978, Sammes et al. J Chem Soc, Faraday Trans 1 281 1986]. [Beilstein 4 IV 284.] CARCINOGEN.
  • Inkompatibilitäten Incompatible (possibly violent reaction; fire and explosions) with oxidizers (chlorates, nitrates,peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.). Keep away from alkaline materials, chemi cally active metals, strong acids, strong bases.
  • Waste disposal Excess hexamethylphosphoramide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
Hexamethylphosphoramide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Hexamethylphosphorsaeuretriamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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680-31-9, Hexamethylphosphoramide Verwandte Suche:
  • Eastman Inhibitor HPT
  • eastmaninhibitorhpt
  • ENT 50,882
  • ENT 50882
  • Hexmethylphosphoramide
  • HMPTA
  • HPT
  • Phosphoric acid hexamethyltriamide
  • Phosphoric hexamethyltriamide
  • Phosphoric triamide, hexamethyl-
  • Phosphoric Tris(dimethylamide)
  • phosphoricacidhexamethyltriamide
  • Phosphorictriamide,hexamethyl-
  • phosphorictris(dimethylamide)
  • Phosphoryl hexamethyltriamide
  • phosphorylhexamethyltriamide
  • Tri(dimethylamino)phosphineoxide
  • Tris-(dimethylamid) kyseliny fosforecne
  • tris-(dimethylamid)kyselinyfosforecne
  • HEXAMETHYL PHOSPHORAMID
  • Hexamethylphosphoriv triamid
  • TRIS(DIMETHYLAMINO)PHOSPHINE OXIDE
  • N,N,N',N',N'',N''-Hexamethylphosphoric triamide, Tris(dimethylamino)phosphine oxide, HMPA
  • HEXANETHYLPHOSPHORAMIDE
  • hexamethylphosphoric triamide hexamethylphosphoramide
  • Hexamethylphosphoric acid triamide, HMPA, Tris(dimethylamino)phosphine oxide
  • Hexamethylphosphoramide,98%
  • Hexamethylphosphoramide,99%
  • Hexamethyl phosphoryl triamide ,99%
  • Hexamethylphosphoramide,HMPA, Hexamethylphosphoric acid triamide, Tris(dimethylamino)phosphine oxide
  • Hexamethylphosphoric triamide 1g [680-31-9]
  • Hexamethylphosphoric triamide 3g [680-31-9]
  • Hexamethylphosphoram
  • HexaMethyl Phosphoryl TriaMide(HMpa )
  • HexaMethyl phosphoryl three aMine
  • Hexamethylphosphoramide absolute, over molecular sieve (H2O <=0.01%), >=98.0% (GC)
  • HexaMethyltriaMidophosphate
  • HexaMethylphosphoraMide puruM, >=98.0% (GC)
  • HEXAMETHYLPHOSPHORAMIDE, 99%HEXAMETHYLPHOSPHORAMIDE, 99%HEXAMETHYLPHOSPHORAMIDE, 99%
  • N,N,N,N,N,N-Hexamethylphosphoric triamide
  • PHOSPHORIC ACID TRIS(DIMETHYLAMIDE)
  • HMPA
  • HEXAMETHYLPHOSPHAMIDE
  • HEXAMETHYLPHOSPHORAMIDE
  • HEXAMETHYLPHOSPHORIC ACID TRIAMIDE
  • HEXAMETHYLPHOSPHORIC TRIAMIDE
  • HEXAMETHYLPHOSPHOROTRIAMIDE
  • HEXAMETAPOL
  • AURORA KA-1674
  • Hexamethylphosphoramide-D18(D, 98%)
  • ent50,882
  • ent50882
  • examethyltriamidophosphate
  • HEMPA
  • hexamethyl
  • Hexamethylfosforamid
  • Hexamethylorthophosphoric triamide
  • hexamethylphosphoramide(hmpa)