Hexamethylphosphorsaeuretriamid

Bezeichnung:Hexamethylphosphorsaeuretriamid

CAS-Nr680-31-9

Englisch Name:Hexamethylphosphoramide

CBNumberCB1177006

SummenformelC6H18N3OP

Molgewicht179.2

MOL-Datei680-31-9.mol

Synonyma

Hexamethylphosphorsaeuretriamid

Hexamethylphosphoramid

Hexamethylphosphamid

Hexamethylphosphorsaeuretriamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	7 °C (lit.)
Siedepunkt	230-232 °C/740 mmHg (lit.)
Dichte	1.03 g/mL at 25 °C (lit.)
Dampfdichte	6.18 (vs air)
Dampfdruck	0.07 mm Hg ( 25 °C)
Brechungsindex	n20/D 1.459(lit.)
Flammpunkt	222 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform (Soluble), Methanol (Slightly)
pka	4.69±0.70(Predicted)
Aggregatzustand	liquid
Farbe	Colorless to light yellow liquid
Geruch (Odor)	Spicy odor (no threshold data)
Wasserlöslichkeit	Miscible
FreezingPoint	7℃
Merck	14,4725
BRN	1099903
Dielectric constant	30.0（20℃）
Stabilität	Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKey	GNOIPBMMFNIUFM-UHFFFAOYSA-N
CAS Datenbank	680-31-9(CAS DataBase Reference)
IARC	2B (Vol. 15, Sup 7, 71) 1999
NIST chemische Informationen	N,N,N',N',N",N'-Hexamethylphosphorotriamide(680-31-9)
EPA chemische Informationen	Hexamethylphosphoramide (680-31-9)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	45-46
S-Sätze:	53-45-99
RIDADR	2810
WGK Germany	3
RTECS-Nr.	TD0875000
F	8
HazardClass	6.1(b)
PackingGroup	III
HS Code	29299090
Giftige Stoffe Daten	680-31-9(Hazardous Substances Data)
Toxizität	LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)

Gefahreninformationscode (GHS)

Hexamethylphosphoramide Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE, BEWEGLICHE FLüSSIGKEIT.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen oder Verbrennen unter Bildung giftiger Rauche mit Phosphoroxiden, Stickstoffoxiden.
ARBEITSPLATZGRENZWERTE
TLV: Hautresorption Krebskategorie A3 (bestätigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK: Hautresorption; Krebserzeugend Kategorie 2; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und über die Haut.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Möglich sind Auswirkungen auf Lunge, Nieren und Zentralnervensystem mit nachfolgenden Funktionsstörungen und Depression.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglich sind Auswirkungen auf Atemwege, Nieren und Knochenmark. Möglicherweise krebserzeugend für den Menschen. Kann zu genetischen Schäden führen.
LECKAGE
Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.
R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R46:Kann vererbbare Schäden verursachen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Hexamethylphosphoric triamide is a colorlessliquid with a spicy odor. Molecular weight = 179.24; .Specific gravity (H2O:1l)= 1.03; Boiling point= 232.8℃;FreezingMelting point = 6.1℃; Relative vapor density(air= 1)=6.18; V apor pressure = 0.03 mmHg at 20℃;Flash point= 104.4℃. Hazard Identification (basedonNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0. Soluble in water.
Chemische Eigenschaften
colourless or light amber liquid with an aromatic spicy odour
Chemische Eigenschaften
Hexamethylphosphoric triamide is a colorless liquid with a spicy odor.
Verwenden
Solvent for polymers; polymerization catalyst; stabilizer against thermal degradation in polystyrene; UV stabilizer in polyvinyl and polyolefin resins
Verwenden
Hexamethylphosphoramide is a dipolar co-solvent and an effective additive used in reactions like reduction of halides, deoxygenation of sulfones, halide olefin couplings and cleavage of carbon-sulfur bond.
Verwenden
Aprotic solvent in organic synthesis. Solvent for polymers, gases; polymerization catalyst; thermal stabilizer in polystyrene; protective additive for polyvinyl and polyolefin resins against uv light degradation. De-icing additive for jet fuels. Chemosterilant for a number of insect pests; chemical mutagen.
Definition
ChEBI: Hexamethylphosphoric triamide is a phosphoramide. It has a role as a mutagen and an insect sterilant.
Allgemeine Beschreibung
Clear colorless to light amber liquid with a spicy odor.
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Hexamethylphosphoramide may react with strong oxidizing agents and strong acids . Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Hazard
Possible carcinogen. Toxic by skin contact. Combustible.
Health Hazard
The acute toxicity of hexamethylphosphoramide is low. HMPA can cause irritation upon contact with the skin and eyes. Hexamethylphosphoramide has been found to cause cancer in laboratory animals exposed by inhalation and meets the criteria for classification as an OSHA "select carcinogen." Chronic exposure to HMPA can cause damage to the lungs and kidneys. Reproductive effects in male animals treated with hexamethylphosphoramide have been observed. HMPA should be regarded as a substance with poor warning properties.
Brandgefahr
Hexamethylphosphoramide is combustible.
Brandgefahr
Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.
Flammability and Explosibility
Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.
mögliche Exposition
Hexamethylphosphoric triamide is a material possessing unique properties and is widely used as a solvent in small quantities, in organic and organometallic reactions in laboratories. This is the major source of occu pational exposure to HMPA in the United States. It is also used as a processing solvent in the manufacture of aramid fibers. HMPA has been evaluated for use as an ultraviolet light absorber or inhibitor in polyvinylchloride formulations; as an additive for antistatic effects; as a flame retardant; and as a deicing additive for jet fuels. Hexamethylphosphoric triamide has also been extensively investigated as an insect chemosterilant.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek med-ical attention immediately. If this chemical contacts theskin, remove contaminated clothingand wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Carcinogenicity
Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Lager
this compound should be handled only in a fume hood, using appropriate impermeable gloves and splash goggles to prevent skin and eye contact. Containers of this substance should be stored in secondary containers.
Versand/Shipping
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required
läuterung methode
The industrial synthesis is usually by treatment of POCl3 with excess of dimethylamine in isopropyl ether. Impurities are water, dimethylamine and its hydrochloride. It is purified by refluxing over BaO or CaO at about 4mm pressure in an atmosphere of nitrogen for several hours, then distilled from sodium at the same pressure. The middle fraction (b ca 90o) is collected, refluxed over sodium under reduced pressure under nitrogen and distilled. It is kept in the dark under nitrogen, and stored in solid CO2. It can also be stored over 4A molecular sieves. Alternatively, it is distilled under vacuum from CaH2 at 60o and is crystallised twice in a cold room at 0o, seeding the liquid with crystals obtained by cooling in liquid nitrogen. After about two-thirds are frozen, the remaining liquid is drained off [Fujinaga et al. Pure Appl Chem 44 117 1975]. For tests of purity see Fujinaga et al. in Purification of Solvents, Coetzee Ed., Pergamon Press, Oxford, 1982. For efficiency of desiccants in drying HMPA see Burfield and Smithers [J Org Chem 43 3966 1978, Sammes et al. J Chem Soc, Faraday Trans 1 281 1986]. [Beilstein 4 IV 284.] CARCINOGEN.
Inkompatibilitäten
Incompatible (possibly violent reaction; fire and explosions) with oxidizers (chlorates, nitrates,peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.). Keep away from alkaline materials, chemi cally active metals, strong acids, strong bases.
Waste disposal
Excess hexamethylphosphoramide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.

Hexamethylphosphoramide Upstream-Materialien And Downstream Produkte

Hexamethylphosphorsaeuretriamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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