sn-Glycero-3-phosphocholine Struktur

Cholinglycerophosphat

Bezeichnung:Cholinglycerophosphat

CAS-Nr28319-77-9

Englisch Name:sn-Glycero-3-phosphocholine

CBNumberCB5309777

SummenformelC8H20NO6P

Molgewicht257.22

MOL-Datei28319-77-9.mol

Synonyma

Cholinglycerophosphat

Cholinglycerophosphat physikalisch-chemischer Eigenschaften

Schmelzpunkt	142.5-143°
alpha	D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8)
Siedepunkt	480℃[at 101 325 Pa]
Dampfdruck	0Pa at 25℃
Flammpunkt	11 °C
storage temp.	-20°C
Löslichkeit	DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly)
Aggregatzustand	solid
Farbe	White to Off-White
Wasserlöslichkeit	1000g/L at 25℃
Stabilität	Very Hygroscopic
InChI	InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
InChIKey	SUHOQUVVVLNYQR-SBYBRXNCNA-N
SMILES	P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO \|&1:12,r\|
LogP	-5.15 at 25℃
CAS Datenbank	28319-77-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25
S-Sätze:	16-36/37-45-24/25
RIDADR	UN 1230 3/PG 2
WGK Germany	2
RTECS-Nr.	KH2775000
HS Code	29239000

Gefahreninformationscode (GHS)

sn-Glycero-3-phosphocholine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
Chemische Eigenschaften
Choline glycerophosphate (GPC) is a white waxy solid that is miscible with water, soluble in methanol and ethanol, and insoluble in chloroform, ether, oil, etc. It has no characteristic absorption under UV visible light. The methods for determining GPC content include high-performance liquid chromatography (equipped with an evaporative light scattering detector or refractive index differential detector) and the digestion phosphorus determination method.
Originator
Sandoz; Italfarmaco (Italy)
Verwenden
L-α-Glycerophosphorylcholine has been used to rescue choline auxotrophy. It has also been used for the synthesis of glycerophospholipids.
Verwenden
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
Definition
ChEBI: Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
Trademarks
Delecit
Allgemeine Beschreibung
L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Increases inositol phosphate formation.
Synthese
10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).

sn-Glycero-3-phosphocholine Upstream-Materialien And Downstream Produkte

Cholinglycerophosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

28319-77-9, sn-Glycero-3-phosphocholine Verwandte Suche:

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