Mazindol

Bezeichnung:Mazindol

CAS-Nr22232-71-9

Englisch Name:Mazindol

CBNumberCB1306743

SummenformelC16H13ClN2O

Molgewicht284.74

MOL-Datei22232-71-9.mol

Synonyma

Mazindol

Mazindol physikalisch-chemischer Eigenschaften

Schmelzpunkt	215-217°C
Siedepunkt	454.9±55.0 °C(Predicted)
Dichte	1.39
Brechungsindex	1.6330 (estimate)
storage temp.	Controlled Substance, -20°C Freezer
Löslichkeit	DMSO: 10 mg/mL
Aggregatzustand	powder
pka	pKa 8.6 (Uncertain)
Farbe	white
CAS Datenbank	22232-71-9(CAS DataBase Reference)
NIST chemische Informationen	Mazindol(22232-71-9)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	NI2975000
HazardClass	6.1(a)
PackingGroup	II
Giftige Stoffe Daten	22232-71-9(Hazardous Substances Data)
Toxizität	LD50 oral in rabbit: 98mg/kg

Gefahreninformationscode (GHS)

Mazindol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Originator
Sanorex ,Sandoz ,US ,1973
Verwenden
Clinical trials as appetite depressant. Anorexic; CNS stimulant. Controlled substance (stimulant).
Definition
ChEBI: Mazindol is an organic molecular entity.
Manufacturing Process
Step 1: 1-(p-Chlorophenyl)-3-Ethoxy-11H-Isoindole - Crystalline triethyloxonium borontetrafluoride (21 g) (prepared from 23 g of borontrifluoride etherate and 11 g of epichlorohydrin) is dissolved in 100 ml of absolute methylenechloride. 3-(p-Chlorophenyl) phthalimidine (21 g) is added and the reaction mixture is stirred overnight at room temperature. The resulting solution is poured onto 50 ml of saturated sodium carbonate, extracted with 500 ml of ether and dried. Upon evaporation of the solvent there is obtained crude material which is recrystallized from methylene chloride/hexane (1:1) to yield 1-(p-chlorophenyl)-3-ethoxy-1H-isoindole; MP 102° to 103°C.
Step 2: 5-(p-Chlorophenyl)-5-Hydroxy-2,3-Dihydro-5H-Imidazo[2,1- a]Isoindole - 1-(p-Chlorophenyl)-3-ethoxy-1H-isoindole (1 g), 2 g of ethyleneimine hydrotetrafluoroborate moistened with methylene chloride (containing approximately 0.66 g of dry salt) is refluxed in 25 ml of absolute toluene for 2 hours in an atmosphere of nitrogen. The resulting mixture is poured into 2 N sodium carbonate solution (25 ml) and extracted with ether. The ether solution is contacted with air for 6 days at room temperature to give the desired product. The crude material is recrystallized from acetone/hexane (1:1) to give 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5Himidazo[2,1-a]isoindole; MP 198° to 199°C.
Trademarks
Mazanor (Wyeth); Sanorex (Novartis);Dasten;Degonon;Fagolipo;Lipese;Magrilan;Mazanor tablets;Mazeldene;Mazinil;Maznor;Tenorac.
Therapeutic Function
Antiobesity
Weltgesundheitsorganisation (WHO)
Mazindol, an anorectic agent, was introduced into medicine in 1970 as an aid to weight reduction. It is controlled under Schedule IV of the 1971 Convention on Psychotropic Substances. It remains available in many countries with highly evolved drug regulatory authorities. (Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV), , , 1971)

Mazindol Upstream-Materialien And Downstream Produkte

22232-71-9, Mazindol Verwandte Suche:

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