Indolin

Bezeichnung:Indolin

CAS-Nr496-15-1

Englisch Name:Indoline

CBNumberCB5485525

SummenformelC8H9N

Molgewicht119.16

MOL-Datei496-15-1.mol

Synonyma

Indolin

Indolin physikalisch-chemischer Eigenschaften

Schmelzpunkt	-21 °C
Siedepunkt	220-221 °C (lit.)
Dichte	1.063 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.592(lit.)
Flammpunkt	199 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	5g/l; lnsoluble in water, soluble in alcohol and oils. Poorly soluble in Propylene glycol.
Aggregatzustand	liquid (clear)
pka	5.20±0.20(Predicted)
Farbe	clear dark brown
Geruch (Odor)	a mild, delicate, but extremely tenacious floral odor
Wasserlöslichkeit	5 g/L (20 ºC)
Sensitive	Light Sensitive
BRN	111915
CAS Datenbank	496-15-1(CAS DataBase Reference)
NIST chemische Informationen	1H-Indole, 2,3-dihydro-(496-15-1)
EPA chemische Informationen	1H-Indole, 2,3-dihydro- (496-15-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	23-24/25-37/39-26
WGK Germany	3
RTECS-Nr.	NL6906300
Hazard Note	Irritant
TSCA	Yes
HS Code	29339990

Gefahreninformationscode (GHS)

Indoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
?2,3-Dihydroindole [496-15-1], indoline C8H9N, Mr 119.16, bp 229 – 230 ℃(101.3 kPa), is a colorless liquid, which is volatile in steam and soluble in diethyl ether, acetone, and benzene, but only slightly soluble in water. Indoline is obtained by hydrogenation of indole or by catalytic cyclodehydration of 2-(2-aminophenyl)ethanol. A range of pharmaceuticals, as well as fungicides and bactericides, can be produced from indoline.
Verwenden
As an indole derivative, Indoline can be used in the preparation of various medicinal compounds such as potential α1-adrenoceptor (α1-AR) antagonists.
Verwenden
Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. Indole and its derivatives are widely used in making perfumes, dyes, agrochemicals and medicines.
Verwenden
Reactant for preparation of:
- Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
- Sphingosine-1-phosphate 4(S1P4) receptor antagonists
- Cytotoxic cell cycle inhibitors
- 2-Aminopyridines
- PET agent for imaging of protein kinase C (PKC)
- Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
- α4β2-Nicotinic acetylcholine receptor-selective partial agonists
- mGlu4 positive allosteric modulators
- Bacterial biofilm inhibitors
- Serotonin 5-HT6 receptor antagonists
Definition
ChEBI: Indoline is a member of indoles.
Synthesis Reference(s)
Journal of the American Chemical Society, 96, p. 7812, 1974 DOI: 10.1021/ja00832a035
Synthetic Communications, 13, p. 489, 1983 DOI: 10.1080/00397918308081827
Synthese
Indolene is manufactured from (theoretically) 2 Mol. Indole plus 1 Mol. Hydroxycitronellal by condensation under heating. The proportions may vary slightly, and it is common practice to add Diethyl phthalate to the mixture prior to heating, so that the condensation product is somewhat protected against local overheating, and the finished product becomes light of color and fairly pourable at room temperature.

Indoline Upstream-Materialien And Downstream Produkte

Indolin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

496-15-1, Indoline Verwandte Suche:

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