Benzocain Produkt Beschreibung

Benzocaine Struktur
94-09-7
  • CAS-Nr.94-09-7
  • Bezeichnung:Benzocain
  • Englisch Name:Benzocaine
  • Synonyma:Benzocain
    Solu H;Norcain;Ora-jel;NSC 4688;Ethoform;Norcaine;Topcaine;ORTHESIN;Euphagin;Anaesthin
  • CBNumber:CB1217951
  • Summenformel:C9H11NO2
  • Molgewicht:165.19
  • MOL-Datei:94-09-7.mol
Benzocain physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :88-90 °C
  • Siedepunkt: :172 °C (12.7517 mmHg)
  • Dichte :1.17
  • Brechungsindex :1.5600 (estimate)
  • Flammpunkt: :172°C/13mm
  • storage temp.  :2-8°C
  • Löslichkeit :alcohol: soluble1 gm in 5 ml
  • Aggregatzustand :Crystalline Powder
  • pka :2.5(at 25℃)
  • Farbe :White
  • Wasserlöslichkeit :Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water
  • Merck  :14,1086
  • BRN  :638434
  • Stabilität: :Stable. Combustible. Incompatible with strong oxidizing agents.
  • InChIKey :BLFLLBZGZJTVJG-UHFFFAOYSA-N
  • CAS Datenbank :94-09-7(CAS DataBase Reference)
  • NIST chemische Informationen :Benzoic acid, 4-amino-, ethyl ester(94-09-7)
  • EPA chemische Informationen :Benzocaine (94-09-7)
Sicherheit

Benzocaine Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R43:Sensibilisierung durch Hautkontakt möglich.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S24/25:Berührung mit den Augen und der Haut vermeiden.
    S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S24:Berührung mit der Haut vermeiden.
  • Beschreibung Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
    Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.
  • Chemische Eigenschaften white odourless crystals
  • Verwenden Benzocaine is used as an anesthetic (local).
  • Verwenden Local and topical anesthetic used in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.
  • Verwenden Apply to a maximum of three to four times a day to the affected area, as directed by the physician.
  • Trademarks Americaine (Fisons); Baby Anbesol (Whitehall-Robins).
  • Biologische Funktion Benzocaine is a PABA derivative used primarily for topical application to skin and mucous membranes. Its low aqueous solubility allows it to stay at the site of application for long periods. Its minimal rate of absorption after topical administration is associated with a low incidence of systemic toxicity. Benzocaine is contraindicated in patients with known sensitivity to ester-linked anesthetics or PABA-containing compounds.
  • Synthesis Reference(s) Journal of the American Chemical Society, 71, p. 4154, 1949 DOI: 10.1021/ja01180a513
    Chemical and Pharmaceutical Bulletin, 29, p. 1443, 1981 DOI: 10.1248/cpb.29.1443
  • Allgemeine Beschreibung Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH.Because it is uncharged, it is not water soluble but is ideal fortopical applications. The onset of action is within 30 secondsand the duration of drug action is 10 to 15 minutes.
  • Biochem/physiol Actions Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the nerve membrane, stopping the propagation of the action potential.
  • Clinical Use Benzocaine is used for endoscopy, bronchoscopy, and topicalanesthesia. Benzocaine is available as a 20% solution topicalspray, in a 1% gel for mucous membrane application, and a14% glycerin suspension for topical use in the outer ear.Toxicity to benzocaine can occur when the topical doseexceeds 200 to 300 mg resulting in methemoglobinemia.Infants and children are more susceptible to this and methemoglobinemiahas been reported after benzocaine lubricationof endotracheal tubes and after topical administration to treata painful diaper rash.
  • Sicherheitsprofil Poison by ingestion and intraperitoneal routes. Human systemic effects by rectal route: methemoglobinemia/carboxyhemoglobinem ia in infants. A skin irritant and a mild sensitizer. Local contact may cause contact dermatitis. Used as a topical anesthetic and as a sun-screening agent. When heated to decomposition it emits highly toxic fumes of NOx. See also ETHYL ALCOHOL and ESTERS
  • Chemical Synthesis Benzocaine is the ethyl ester of 4-aminobenzoic acid (2.3.1). The classic, optimal way of benzocaine synthesis is the reduction of the nitro group of the ethyl ester of 4-nitrobenzoic acid to benzocaine by hydrogen, which generates directly in the reaction medium by the reaction of iron filings with dilute acids [24–26].

  • läuterung methode Crystallise Benzocaine from EtOH/H2O or EtOH (m 93-94o), and dry it in air. [Beilstein 14 H 422, 14 IV 1129.]
  • Structure and conformation Ethyl aminobenzoate, a para-aminobenzoate derivative (PABA)
Benzocaine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Benzocain Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global(610)Suppliers
  • Firmenname:Hebei Crovell Biotech Co Ltd
  • Telefon:+86-19930503285 +86-19930503285
  • Fax:86-0311-66562153
  • E-Mail:zoey@crovellbio.com
  • Land:China
  • Produktkatalog:3196
  • Edge Rate:58
  • Firmenname:career henan chemical co
  • Telefon:+86-0371-55982848
  • Fax:
  • E-Mail:sales@coreychem.com
  • Land:China
  • Produktkatalog:29953
  • Edge Rate:58
94-09-7, Benzocaine Verwandte Suche:
  • NSC 4688
  • Benzocaine (See B197952 for Labelled)
  • Benzocaine, USP, EP
  • Ethyl 4-aMinobenzoate, 98% 100GR
  • Ethyl 4-aMinobenzoate, 98% 500GR
  • (p-(Ethoxycarbonyl)phenylaMine
  • 4-(Ethoxycarbonyl)phenylaMine
  • 4-Aminobenzoic Acid Ethyl Ester Benzocaine
  • The aMino acid ethyl ester
  • Benzocaine solution
  • Ethyl 4-aminobenzoate 98%
  • Ethyl 4-aminobenzoate Vetec(TM) reagent grade, 98%
  • Benzocaine, >=99%
  • Anaesthesin
  • Anaesthin
  • Anestezin
  • Anesthesine
  • Anesthone
  • Baby Anbesol
  • Benzoic acid, p-amino-, ethyl ester
  • Benzoicacid,4-amino-,ethylester
  • component of Anbesol maximum strength
  • component of Cough-x
  • component of Outgro
  • component of Solarcaine aerosol
  • component of Tympagesic
  • Dermoplast
  • Ethoform
  • Ethyl p-aminophenylcarboxylate
  • Ethylester kyseliny p-aminobenzoove
  • ethylesterkyselinyp-aminobenzoove
  • Hurricaine
  • Identhesin
  • Norcain
  • Norcaine
  • Ora-jel
  • p-(Ethoxycarbonyl)aniline
  • p-amino-benzoicaciethylester
  • Parathesine
  • p-Carbethoxyaniline
  • p-Ethoxycarboxylic aniline
  • Solarcaine
  • Solu H
  • Topcaine
  • Snow Lotus Herb Extract
  • Anaesthesine,Ethyl Aminobenzoate
  • benzocaine powder
  • Benzocain raw material,Benzocain hcl,Benzocain Hydrochloride
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