5-Carboxy-8-hydroxyquinoline

Bezeichnung:5-Carboxy-8-hydroxyquinoline

CAS-Nr5852-78-8

Englisch Name:5-Carboxy-8-hydroxyquinoline

CBNumberCB02671446

SummenformelC10H7NO3

Molgewicht189.17

MOL-Datei5852-78-8.mol

5-Carboxy-8-hydroxyquinoline physikalisch-chemischer Eigenschaften

Schmelzpunkt	301 °C (decomp)
Siedepunkt	464.5±30.0 °C(Predicted)
Dichte	1.480±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble10mg/mL, clear
pka	1.82±0.10(Predicted)
Aggregatzustand	powder
Farbe	white to brown
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey	JGRPKOGHYBAVMW-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
HS Code	2933499090

Gefahreninformationscode (GHS)

5-Carboxy-8-hydroxyquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1?A broad spectrum 2-oxoglutarate oxygenase inhibitor, IOX 1 may be used to study hypoxic signaling.1?Cell permeable
Verwenden
8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
Verwenden
IOX1 has been used:
- To eliminate viral latency in latent viruses in order to sensitize the viral infections to antiviral therapy.
- In histone lysine demethylase 4A (KDM4A) inhibition, to serve as a unique strategy to decrease hypoxia-inducible factors signalling.
- to restore oncogene-induced senescence in wild-type mouse embryo fibroblasts.
Verwenden
5-Carboxy-8-hydroxyquinoline is an inhibitor of KDM2/7 histone demethylase. 5-Carboxy-8-hydroxyquinoline has also shown potential to be used as a regulator of plant growth.
Definition
ChEBI: 8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.
Biochem/physiol Actions
IOX1 (5-Carboxy-8-hydroxyquinoline) is a broad spectrum inhibitor of 2-oxoglutarate (2OG) oxygenases, including Jumonji C domain (JmjC) demethylases. It is useful for the study of histone demethylation and hypoxic sensing and results in translocation of active site iron on the 2OG oxygenases. For full characterization details, please visit the IOX1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Lager
Store at +4°C
Einzelnachweise
1) King et al. (2010), Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors; PLoS One, 5 e15535

5-Carboxy-8-hydroxyquinoline Upstream-Materialien And Downstream Produkte

5-Carboxy-8-hydroxyquinoline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5852-78-8, 5-Carboxy-8-hydroxyquinoline Verwandte Suche:

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