Cefetamet hydrochloride

Bezeichnung:Cefetamet hydrochloride

CAS-Nr65052-63-3

Englisch Name:Cefetamet hydrochloride

CBNumberCB0266851

SummenformelC14H15N5O5S2

Molgewicht397.43

MOL-Datei65052-63-3.mol

Cefetamet hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	>178°C (dec.)
Dichte	1.83±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka	3.11±0.50(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Hygroscopic
CAS Datenbank	65052-63-3(CAS DataBase Reference)

Sicherheit

HS Code

2941906000

Gefahreninformationscode (GHS)

Cefetamet hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Ceftazidime hydrochloride is an oral third-generation cephalosporin, which has the same antibacterial activity against gram-positive bacteria as cefixime, and is superior to cefaclor, especially against Streptococcus pneumoniae and Streptococcus pyogenes. It has obvious antibacterial activity against a variety of gram-negative bacteria such as Escherichia coli, Proteus, Klebsiella pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae, especially against Serratia, indole-positive Proteus, Enterobacter The antibacterial activity of Citrobacter and Citrobacter was significantly enhanced.
Verwenden
Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.
Definition
ChEBI: Cefetamet is a cephalosporin compound having methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups; a cephalosporin antibiotic active against Neisseria gonorrhoeae.
Antimicrobial activity
A semisynthetic cephalosporin formulated for oral use as the prodrug ester, cefetamet pivoxyl. It is less active than cefaclor and cefadroxil against Staph. aureus, but as active against streptococci and more active against enterobacteria, H. influenzae and N. gonorrhoeae, including β-lactamase-producing strains. L. monocytogenes, C. difficile, Sten. maltophilia and Burk. cepacia are all resistant. It is resistant to hydrolysis by common plasmid-mediated enzymes.
The absolute bioavailability is about 50%. The plasma peak is delayed by food. Binding to plasma protein is about 20%. The volume of distribution approximates to the extracellular water. It is excreted into urine with a half-life of 2–2.5 h, principally in the glomerular filtrate. Elimination is linearly related to creatinine clearance. Side effects and uses are similar to those of other group 5 cephalosporins.

Cefetamet hydrochloride Upstream-Materialien And Downstream Produkte

Cefetamet hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

65052-63-3, Cefetamet hydrochloride Verwandte Suche:

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