5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]-

Bezeichnung:5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]-

CAS-Nr75738-58-8

Englisch Name:Cefmenoxime hydrochloride

CBNumberCB7763319

SummenformelC16H18ClN9O5S3

Molgewicht548.01

MOL-Datei75738-58-8.mol

Synonyma

5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]-

5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]- physikalisch-chemischer Eigenschaften

Schmelzpunkt	>175°C (dec.)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	DMSO (Slightly, Heated), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Off-White to Pale Yellow
InChIKey	HZYJYGJIOCXOTH-AJVJENPNNA-N
SMILES	C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NN=NN1C)(=O)O.Cl \|&1:5,7,r\|

Sicherheit

HS Code

2941906000

Gefahreninformationscode (GHS)

Cefmenoxime hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Cef menoxime hydrochloride is a third generation cephalosporin antibiotic. Structurally, it possesses the (1-methyl-lH-tetrazol-5-yl)thiomethyl moiety in the 3-position; like several other compounds containing this structural element (moxalactam, cefoperazone, cefamandol), bleeding linked to vitamin K interaction has been reported. Cefmenoxime has activity similar to cefotiuime, ceftizoxime and moxalactam against E.coli, C. diversus, Klebsiella, P. Mirabilis, Salmonella, Shigella, Neiseria spp., S. pyogenes, S. Pneumoniae, and g. influenzae. It is relatively ineffective against Pseudomonas and Bacteroidea.
Originator
Takeda (Japan)
Verwenden
A third generation cephalosporin antibiotic with strong antimicrobial activities against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella subgenus Branhamella catarrhalis that were 3 major aerobic bacteria from sinusitis.
Verwenden
antibacterial
Definition
ChEBI: The hemihydrochloride salt of cefmenoxime.
Trademarks
Cefmax (TAP);TACEF;BESTCALL.
Allgemeine Beschreibung
Cefmenoxime was synthesized by Takeda Pharmaceutical Co. in 1978. It contains aminothiazole and methoxyimino groups in the 7-acyl position and a methyltetrazole group at the 3 position of the cephem nucleus. Cefmenoxime has a wide activity spectrum against gram-positive and gram-negative bacteria, including anaerobes, except Staphylococcus aureus. Cefmenoxime is a member of the so-called third-generation cephalosporins, a recently introduced class of clinically important antibiotics.

5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Hydrochlorid (2:1), [6R-[6α,7β(Z)]]- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

75738-58-8, Cefmenoxime hydrochloride Verwandte Suche:

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