盐酸地匹福林

盐酸地匹福林化学性质

熔点 :158-159°
储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度 :Freely soluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent) and in methylene chloride.
酸度系数(pKa) :8.40(at 25℃)
形态 :Solid
颜色 :White to Off-White
InChI :InChI=1S/C19H29NO5.ClH/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6;/h8-10,13,20-21H,11H2,1-7H3;1H
InChIKey :VKFAUCPBMAGVRG-UHFFFAOYSA-N
SMILES :C1(OC(=O)C(C)(C)C)=CC(=CC=C1OC(=O)C(C)(C)C)C(O)CNC.Cl

安全信息

盐酸地匹福林化学药品说明书

生物活性 Dipivefrin hydrochloride (Dipivefrine hydrochloride) 是一种抗青光眼前体药物，通过角膜中的酯酶水解为其活性化合物肾上腺素。

体内研究

Dipivefrin hydrochloride (0.3-10 μg/kg; i.p.;) induces enhancement of memory involves central beta- but not alpha-adrenergic mechanisms.

Animal Model:	Male 60-day-old CFW mice (23-28 g)
Dosage:	0.3 μg/kg, 1.0 μg/kg, 3.0 μg/kg, 10 μg/kg
Administration:	Intraperitoneal injection; post-training
Result:	Significantly enhanced retention of both inhibitory avoidance and Y-maze discrimination tasks in a dose-dependent manner.

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