76-74-4
中文名称
戊巴比妥
英文名称
Pentobarbital
CAS
76-74-4
EINECS 编号
200-983-8
分子式
C11H18N2O3
MDL 编号
MFCD00057561
分子量
226.27
MOL 文件
76-74-4.mol
结构式
基本信息
中文别名
5-乙基-5-(1-甲基丁基)-2,4,6-(1H,3H,5H)-嘧啶三酮
5-乙基-5-(1-甲基丁基)巴比妥酸
戊巴比妥
5-乙基-5-(1-甲基丁基)巴比妥酸
戊巴比妥
英文别名
5-ETHYL-5-[1-METHYLBUTYL]-2,4,6-TRIOXOHEXAHYDROPYRIMIDINE
5-ethyl-5-(1-methylbutyl)barbituric acid
5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
PENTOBARBITAL
pentobarbitone
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-
5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
5-Ethyl-5-(1-methylbutyl)barbituric acidcid
5-ethyl-5-(1-methylbutyl)-barbituricaci
5-Ethyl-5-(1-methylbutyl)malonylurea
5-Ethyl-5-(sec-pentyl)barbituric acid
5-ethyl-5-(sec-pentyl)barbituricacid
6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-4
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-
barbituricacid,5-ethyl-5-(2-pentyl)
component of Emesert
Dorsital
Ethaminal
Ethyl-propylmethylcarbinylbarbituric acid
ethyl-propylmethylcarbinylbarbituricacid
5-ethyl-5-(1-methylbutyl)barbituric acid
5-ethyl-5-pentan-2-yl-1,3-diazinane-2,4,6-trione
PENTOBARBITAL
pentobarbitone
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-
5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
5-Ethyl-5-(1-methylbutyl)barbituric acidcid
5-ethyl-5-(1-methylbutyl)-barbituricaci
5-Ethyl-5-(1-methylbutyl)malonylurea
5-Ethyl-5-(sec-pentyl)barbituric acid
5-ethyl-5-(sec-pentyl)barbituricacid
6(1h,3h,5h)-pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-4
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-
barbituricacid,5-ethyl-5-(2-pentyl)
component of Emesert
Dorsital
Ethaminal
Ethyl-propylmethylcarbinylbarbituric acid
ethyl-propylmethylcarbinylbarbituricacid
所属类别
原料药：其它神经系统用药
物理化学性质
| 熔点 | 129.5°C |
| 沸点 | 367.89°C (rough estimate) |
| 密度 | 1.1376 (rough estimate) |
| 折射率 | 1.4620 (estimate) |
| 闪点 | 9℃ |
| 储存条件 | 2-8°C |
| 溶解度 | Very slightly soluble in water, freely soluble in ethanol. It forms water-soluble compounds with alkali hydroxides and carbonates and with ammonia. |
| 酸度系数(pKa) | pK1:8.11(0) (25°C) |
| 形态 | A neat solid |
| 水溶解性 | 679 mg/L |
| Henry's Law Constant | 1.2×107 mol/(m3Pa) at 25℃, HSDB (2015) |
| CAS 数据库 | 76-74-4(CAS DataBase Reference) |
| NIST化学物质信息 | Pentobarbital(76-74-4) |
| EPA化学物质信息 | Pentobarbital (76-74-4) |
安全数据
| 危险性符号(GHS) |   GHS06,GHS08 |
| 警示词 | 危险 |
| 危险性描述 | H301-H336-H361d |
| 防范说明 | P201-P202-P261-P264-P270-P301+P310 |
| 危险品标志 | T,F |
| 危险类别码 | R25-R63-R39/23/24/25-R36/38-R23/24/25-R11 |
| 安全说明 | S7-S16-S36/37-S45-S36/37/39-S22 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | CQ5775000 |
| REACH 注册登记 | Active |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 2933530000 |
| 毒害物质数据 | 76-74-4(Hazardous Substances Data) |
| 毒性 | A barbiturate that causes CNS depression, apparently due to a facilitation of GABA-ergic inhibition. It appears that the site of action of pentobarbital may be the macromolecular complex made up of a GABA receptor, chloride channel, benzodiazepine-binding site, and picrotoxin-binding site. Barbiturates have been shown to compete for dihydropicrotoxinin-binding sites. In clinical use, barbiturates such as pentobarbital have been largely replaced as sedative-hypnotics by the much safer benzodiazepines. The sedative-hypnotic properties of barbiturates may lead to abuse, as tolerance and dependence are known to occur. In animals, pentobarbital is routinely used for its anesthetic and anticonvulsant properties, as well as for euthanasia. Pentobarbital, like other barbiturates, can induce the metabolism of other compounds by altering cytochrome P450 activity. The oral LD50 in rats is 118 mg/kg. |
知名试剂公司产品信息
76-74-4(sigmaaldrich)
Sigma Aldrich