56-34-8
基本信息
N,N,N-三乙基乙铵氯化物
四乙基氯化铵水合物
氯化四乙胺
四乙基氯化铵(TEAC)
氯化四乙铵
氯化四乙基铵
四乙銨化氯
四乙胺氯化物
四乙基氯化胺
TEA
TEA CHLORIDE
TETRAETHYLAMMONIUM CHLORIDE
Ethanaminium,N,N,N-triethyl-,chloride
n,n,n-triethyl-ethanaminiuchloride
n,n,n-triethylethanaminiumchloride
teac
tetraethyl-ammoniuchloride
Tetraethylammonium choride
TETRAETHYLAMMONIUM CHLORIDE SOLUTION
TETRAETHYLAMMONIUM CHLORIDE, FOR MOLECUL AR BIOLOGY
TETRAETHYLAMMONIUM CHLORIDE, ELECTRO-CHE MICAL GRADE
TETRAETHYLAMMONIUM CHLORIDE NICOTINIC BL OCKING AG
Tetraethylammonium
TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT
AMMONIUM,TETRAETHYL-,CHLORIDE
TETRAETHYLAMINEHYDROCHLORIDE
Tetraethylammonium chloride monohydrate, 99+%
Tetraethylammonium chloride ,98%
物理化学性质
外观性状 | 白色至类白色晶体。 |
熔点 | 39°C |
沸点 | 273.32°C (rough estimate) |
密度 | 1.08 |
折射率 | 1.5480 (estimate) |
储存条件 | Inert atmosphere,Room Temperature |
溶解度 | methanol: 0.1 g/mL, clear, colorless |
溶解度 | 甲醇:0.1 g/mL,澄清,无色 |
形态 | 结晶粉末 |
颜色 | white to light yellow |
PH值 | 4.0 to 7.0(50g/L, 25℃) |
水溶解性 | Soluble in water, ethanol, chloroform, or acetone |
敏感性 | 吸湿性 |
最大波长(λmax) | λ: 260 nm Amax: 0.03 λ: 280 nm Amax: 0.03 |
Merck | 14,9200 |
Merck | 9200 |
检测方法 | T,NMR |
BRN | 3563247 |
稳定性 | 稳定的。与强氧化剂不相容。防潮。 |
InChIKey | YMBCJWGVCUEGHA-UHFFFAOYSA-M |
CAS 数据库 | 56-34-8(CAS DataBase Reference) |
EPA化学物质信息 | Tetraethylammonium chloride (56-34-8) |
安全数据
危险性符号(GHS) | GHS07 |
警示词 | 警告 |
危险性描述 | H315-H319 |
防范说明 | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 |
危险品标志 | Xn,Xi |
危险类别码 | 22-36/37/38 |
危险类别码 | R22-R36/37/38 |
安全说明 | 26-36-37/39 |
安全说明 | S26-S36-S37/39 |
WGK Germany | 3 |
WGK Germany | 3 |
RTECS号 | BS6125000 |
F | 3-10 |
TSCA | Yes |
海关编码 | 29239000 |
毒性 | LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.) |
常见问题列表
(1) 将45g氯乙烷溶于300g二甲苯中,待用; (2) 将10g三乙胺、50g乙醚、150g二甲苯加入高压反应爸中,于70°C下,向高压反应爸 中滴加250g氯乙烷-二甲苯溶液,滴加完毕后,保温反应半小时后,通入气体保持高压釜内 压力为3MPa,于120°C下反应12小时后,停止通气,缓慢打开放气阀,降温至室温; (3) 将步骤⑵所得反应液过滤,得58.3g滤饼A为四乙基氯化铵粗品,将四乙基氯化铵 粗品加入100g水中,于45°C下搅拌至大部分粗品溶解,趁热过滤,得20.2g滤液加入80g乙 腈、120g戊二醇混合溶剂中,搅拌静置半小时后,过滤,滤饼B烘干即得15.9g四乙基氯化铵, 纯度为99.7%,收率为95.5%。
四乙基氯化铵是一种非选择性的钾通道 (potassium channel) 阻滞剂,它是有机阳离子转运蛋白的良好底物,并具有抗肿瘤特性。
Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner.
Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells.
Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner.
The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium.
Cell Proliferation Assay
Cell Line: | Rat C6 and 9L glioma cells |
Concentration: | 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM |
Incubation Time: | 24 hours, 48 hours and 72 hours |
Result: | Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner. |
Apoptosis Analysis
Cell Line: | Rat C6 and 9L glioma cells |
Concentration: | 40 mM |
Incubation Time: | 24 hours, 48 hours and 72 hours |
Result: | Significantly increased apoptosis in cells. |
Western Blot Analysis
Cell Line: | Rat C6 and 9L glioma cells |
Concentration: | 40 mM |
Incubation Time: | 12 hours, 24 hours, 48 hours |
Result: | The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h. |
四乙基氯化铵(1 mM、3 mM 和 5 mM)显着增加大鼠结肠和直肠在纵向和环形方向上的收缩幅度和频率。 5 mM 和 15 mM 的四乙基氯化铵对从肛门向结肠腔内局部施用四乙基铵的大鼠的结肠和直肠组织学没有影响 10 天。
知名试剂公司产品信息
Tetraethylammonium chloride hydrate, 99%(56-34-8) Acros Organics
Tetraethylammonium Chloride,>98.0%(T)(56-34-8) TCI Shanghai
四乙基氯化铵价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/11/08 | J62507 | 四乙基氯化铵 Tetraethylammonium chloride | 56-34-8 | 25g | 394元 |
2024/11/08 | J62507 | 四乙基氯化铵 Tetraethylammonium chloride | 56-34-8 | 100g | 1654元 |
2024/11/08 | T0095 | 四乙基氯化铵 Tetraethylammonium Chloride | 56-34-8 | 25G | 230元 |