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548-83-4

供应商 相关产品 基本信息 物理化学性质 常见问题列表 理化性质 应用领域 安全数据 知名试剂公司产品信息 高良姜素价格(试剂级)

产品图片

基本信息

中文
高良姜素
英文名称
3,5,7-trihydroxy-2-phenyl-chromen-4-one
3,5,7-TRIHYDROXYFLAVONE
GALANGIN
NORIZALPININ
3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on
3,5,7-trihydroxy-flavon
3,5,7-trihydroxy-2-phenyl-4-benzopyrone
3,5,7-Trihydroxyflavone (Galangin)
3,5,7-Trihydroxyflavone,97%
GALANGIN hplc
GALANGIN WITH HPLC
2-Phenyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one
3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Galengin
CAS
548-83-4
中文名称
3,5,7-三羟基黄酮
高良姜素
高良姜精
3,5,7-三羟基-2-苯基-4H-1-苯并呋喃-4-酮
3,5.7-三羟基黄酮
EINECS 编号
208-960-4
分子式
C15H10O5
MDL 编号
MFCD00006833
分子量
270.24
MOL 文件
548-83-4.mol

物理化学性质

外观性质
微黄色针状结晶(乙醇), 尚易溶于乙醇及乙醚。在碱的水溶液中成黄色溶液。可升华。熔点:214-215℃
熔点 
214-215 °C(lit.)

Merck 
14,4339
BRN 
272179

常见问题列表

用途
高良姜是一种在高良姜、高良姜和蜂胶中发现的黄烷类物质。高良姜已被证明可以抑制雌激素受体阳性的MCF-7人乳腺癌细胞的增殖,并延缓乳腺肿瘤的发生。
生物活性
Galangin (Norizalpinin) 是 arylhydrocarbon 受体的调节剂,同时抑制 CYP1A1 的活性。
体外研究

Galangin (Norizalpinin) inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner. Galangin also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth. Galangin causes a potent, dose-dependent inhibition of CYP1A1 activity, as measured by ethoxyresorufin-O-deethylase activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that galangin inhibits CYP1A1 activity in a noncompetitive manner. Galangin causes an increase in the level of CYP1A1 mRNA, indicating that it may be an agonist of the aryl hydrocarbon receptor, but it inhibits the induction of CYP1A1 mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD). Galangin also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the CYP1A1 promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.


理化性质

外观性状
淡黄色结晶粉末,易溶于乙醇、乙醚,来源于姜科植物高良姜(Alpinia officinarum Hance)根。
沸点 
333.35°C (rough estimate)
密度 
1.2319 (rough estimate)
折射率 
1.6000 (estimate)
储存条件 
room temp
酸度系数(pKa)
6.32±0.40(Predicted)
InChIKey
VCCRNZQBSJXYJD-UHFFFAOYSA-N
CAS 数据库
548-83-4(CAS DataBase Reference)

应用领域

用途一
能使鼠伤寒沙门氏菌ta98和ta100发生诱变。

安全数据

危险品标志 
Xi
危险类别码 
R36/37/38
安全说明 
S26-S37/39
WGK Germany 
3

RTECS 
LK9275500

RTECS号
LK9275500


10
海关编码
29329990
海关编码 
29329990

知名试剂公司产品信息

高良姜素价格(试剂级)

高良姜素价格(试剂级)
更新日期产品编号产品名称包装价格
2021/05/20L142233,5,7-三羟基黄酮, 97%
3,5,7-Trihydroxyflavone, 97%
25mg1091元
2021/05/20L142233,5,7-三羟基黄酮, 97%
3,5,7-Trihydroxyflavone, 97%
100mg3036元
2021/04/27G0370高良姜精
Galangin
25MG890元

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