供应商 相关产品 基本信息 理化性质 常见问题列表 RG108价格(试剂级)
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48208-26-0

供应商 相关产品 基本信息 理化性质 常见问题列表 RG108价格(试剂级)

产品图片

基本信息

中文
RG108
英文名称
RG108 >98%
RG108/RG-108
N-Phthalyl-L-tryptophan
N-Phthaloyl-L-tryptophan
DNA Methyltransferase Inhibitor
RG108/DNA Methyltransferase Inhibitor/N-Phthalyl-L-tryptophan
(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-
N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid
CAS
48208-26-0
中文名称
N-邻苯二甲酰基-L-色氨酸
分子式
C19H14N2O4
MDL 编号
MFCD08705332
分子量
334.33
MOL 文件
48208-26-0.mol

理化性质

熔点 
192-194℃
储存条件 
Store at RT

常见问题列表

生物活性
RG108是一种DNA甲基转移酶抑制剂,IC50为115 nM,不会引起共价酶的诱捕。
体外研究
RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs.

RG108价格(试剂级)

RG108价格(试剂级)
更新日期产品编号产品名称包装价格
2019/10/12P2023N-酞酰-L-色氨酸
N-Phthalyl-L-tryptophan
50mg345元
2019/10/12P2023N-酞酰-L-色氨酸
N-Phthalyl-L-tryptophan
200mg1115元

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