ChemicalBook CAS DataBase List 9002-61-3

9002-61-3

Name	Chorionic gonadotrophin
CAS	9002-61-3
EINECS(EC#)	232-660-2
Molecular Formula	C17H28
MDL Number	MFCD00130797
Molecular Weight	232.404
MOL File	9002-61-3.mol

Chemical Properties

Appearance	White or yellowish-white, amorphous powder.
storage temp.	2-8°C
solubility	H2O: soluble1ML/vial
form	lyophilized powder
color	White to off-white
biological source	human urine
Water Solubility	water: soluble

Safety Data

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P281
Hazard Codes	B,Xn
Risk Statements	63-62 less more
Safety Statements	22-36-36/37 less more
WGK Germany	3
RTECS	MD6953000
HS Code	2937190000
Storage Class	11 - Combustible Solids
Hazard Classifications	Repr. 2
Hazardous Substances Data	9002-61-3(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

Chemical Properties

White or yellowish-white, amorphous powder.

Uses

Gonad-stimulating principle.

Application

Human chorionic gonadotropin (hCG) is a chemical produced by the trophoblast tissue, which is usually present in the early embryo and will eventually become part of the placenta. Measuring hCG levels helps to identify normal, pathological and miscarried pregnancies. Measuring hCG is also beneficial for many cancers including choriocarcinoma and extrauterine malignancies.

Production Methods

CG is produced in the chorion.

Brand name

A.P.L. (Ferring Pharmaceuticals); Follutein (Bristol-Myers Squibb); Pregnyl (Organon).

General Description

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Biochem/physiol Actions

Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.

Clinical Use

Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the ovaries. Ultrasonograms are used to determine proper follicle maturation before the administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this product is that it can be self-administered by the patient via SC injection.

Veterinary Drugs and Treatments

The veterinary product’s labeled indication is for “parenteral use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.” It has been used for other purposes in several species; refer to the Dosage section for more information.

Supplier

Qingdao Kangyuan Pharmaceutical Co., Ltd.

Telephone0532-86629999，0532-86625577 13905328789

Websitehttp://www.kangyuan.com.cn

Hebei ruqi technology co., ltd

Telephone176-03256889 17603256889

Websitehttp://www.rulintech.com/

Lanzhou Zhichun Chemical Co. LTD

Telephone0931-6800701 18893111699

Websitehttp://www.pure-chem.net/

Hangzhou Ceji Biotechnology Co., Ltd.

Telephone18267142438 18267142438

Website

Chengdu Ai Keda Chemical Technology Co., Ltd.

Telephone4008-755-333 18080918076

Websitehttp://www.aikeshiji.com

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Shanghai JONLN Reagent Co., Ltd.

Telephone400-0066400 13621662912

Websitehttp://www.jonln.com

Chengdu HuaXia Chemical Reagent Co. Ltd

Telephone400-1166-196 13458535857

Websitehttp://www.hx-r.com

Shanghai Macklin Biochemical Co.,Ltd.

Telephone15221275939 15221275939

Websitehttp://www.macklin.cn

Chizhou Kailong Import and Export Trade Co., Ltd.

Telephone

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16778/0_EN.htm

Sigma-Aldrich

Telephone021-61415566 800-8193336

Websitehttps://www.sigmaaldrich.cn

Hangzhou Dingyan Chem Co., LTD

Telephone0571-87157530-8006 18267553885

Websitehttp://www.dingyanchem.com/

Shanghai Xilong Biochemical Technology Co., Ltd.

Telephone021-52907766-8042

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList19329/0_EN.htm

Raw material medicin reagent co.,Ltd

Telephone

Websitehttp://www.njromanme.com

Grader reagent

Telephone18221735425

Websitehttp://www.shxinping.net

Shanghai Orgchem Co.,Ltd.

Telephone+86-21-5877 1921

Websitehttp://www.chemofchina.com

JinJin Le Chemical Co., Ltd

Telephone18001959627(微信同号) 18001959627

Websitehttp://www.jinjinlechem.com

Guangzhou LES biological Technology Co.,Ltd.

Telephone 13672434928;13672434928

Websitehttp://www.les64.com

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