ChemicalBook > Product Catalog > API > Fluid, Electrolyte, and Acid-Base Balance > Electrolyte Balance Pharmacology > Calcium acetate
Basic information Chemical properties Uses Toxicity Usage limit Production method Hazards & Safety Information Safety Related Supplier
Calcium acetate Chemical Properties
- Melting point:160°C (dec.)
- Density 1,5 g/cm3
- FEMA 2228 | CALCIUM ACETATE
- refractive index 1.5500
- Flash point:160°C
- solubility H2O: 1 M at 20 °C, clear, colorless
- form Powder
- color white
- Specific Gravity1.50
- Water Solubility soluble
- Decomposition 160 ºC
- Stability:Stable. Non-flammable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference62-54-4(CAS DataBase Reference)
- EPA Substance Registry SystemCalcium acetate (62-54-4)
Calcium acetate Usage And Synthesis
- Chemical propertiesCalcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It is an odorless powder. Calcium has an important role in the nutrition of humans and animals. Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL. Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.*
- UsesCalcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. It is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life.
- ToxicityADI is not subject to restrictive regulations (FAO/WHO, 2001).
GRAS (FDA, §181.29, §182.6197, § 184.1185, 2000).
LD50: 52 mg/kg (mouse, subcutaneous).
- Usage limitGB 14880 a 94: cereals and their products, beverages 8~16g/kg.
GB 2760-2001: vinegar, 6~8g/kg (in terms of Ca).
FAO/WHO (1984): Edible caseinate, GMP.
FDA, § 184.1185 (2000): baked goods, gelatin, pudding, fillings, 0.2%; sweet sauce, top materials and poured, 0.15%;
EEC can be used for packaging cheese powder, quick-setting jelly powder.
FEMA (mg/kg): soft drinks 200; baked goods 500.
- Production methodIt is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate.
It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization.
It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt.
Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%.
To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated 80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products.
- Hazards & Safety InformationCategory: Toxic substances
Toxicity classification: highly toxic
Acute toxicity: intravenous-mouse LD50: 52 mg/kg; celiac-mouse LD50: 75 mg/kg
Flammability and Hazardous characteristics: Thermal decomposition releases Pungent irritation Smoke
Storage and transportation characteristics:Treasury: ventilated, low temperature drying; store it separately from food raw materials
Fire extinguishing agent: water, dry powder, foam, carbon dioxide
- DescriptionCalcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2?H2O) is the common form.
- Chemical PropertiesCalcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder.
- UsesCalcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c.
- UsesCalcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant.
- DefinitionChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces.
- Production MethodsCalcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar:
CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2
Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then.
- PreparationProduced by calcium hydroxide neutralization of acetic acid.
- Pharmaceutical ApplicationsCalcium acetate is used as a preservative in oral and topical
Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant.
- Safety ProfilePoison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes.
- SafetyCalcium acetate is used in oral and topical formulations. The pure
form of calcium acetate is toxic by IP and IV routes.
LD50 (mouse, IP): 0.075 g/kg
LD50 (mouse, IV): 0.052 g/kg
LD50 (rat, oral): 4.28 g/kg
- Veterinary Drugs and TreatmentsCalcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption.
- storageCalcium acetate is stable although very hygroscopic, and so the
monohydrate is the common form. It decomposes on heating (above
1608℃) to form calcium carbonate and acetone.
Store in well-closed airtight containers.
- Purification MethodsRecrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.]
- IncompatibilitiesCalcium acetate is incompatible with strong oxidizing agents and moisture.
- Regulatory StatusGRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.
Calcium acetate Preparation Products And Raw materials
- Calcium alpha-ketovaline FUMARIC ACID MONOETHYL ESTER, CALCIUM SALT 2'-CALCIUM CITRATE Ketoleucine calcium salt dihydrate CALCIUM L-ARABONATE D-(+)-Pantothenic acid calcium salt Calcium L-lactate 2-KETO-D-GLUCONIC ACID HEMICALCIUM SALT Calcium folinate Pyruvic Acid Calcium Salt Calcium stearate 4-CHLOROBENZOYL-L-TRYPTOPHAN CALCIUM SALT calcium benzamidosalicylate Calcium Propionate CALCIUM OROTATE DL-GLYCERIC ACID HEMICALCIUM SALT HYDRATE Calcium 2-ethylhexanoate 3-METHYL-2-OXOPENTANOIC ACID CALCIUM
- Company Name:J & K SCIENTIFIC LTD.
- Tel:400-666-7788 010-82848833-
- Products Intro:Product Name:Calcium acetate, 99%
- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel:400-660-8290 21-61259100-
- Products Intro:Product Name:CALCIUM ACETATE, Monohydrate
- Company Name:Beijing Ouhe Technology Co., Ltd
- Tel:13552068683 010-82967028-
- Products Intro:Product Name:Calcium acetate
- Company Name:JinYan Chemicals(ShangHai) Co.,Ltd.
- Products Intro:CAS:62-54-4
- Company Name:Adamas Reagent, Ltd.
- Products Intro:Product Name:Acetic Acid CalciuM Salt