828-27-3

139301-27-2

828-27-3

General procedure for the synthesis of 4-trifluoromethoxyphenol from 4-trifluoromethoxyphenylboronic acid: In an atypical method, a flask containing 4-trifluoromethoxyphenylboronic acid (100 mg, 0.82 mmol) was taken to which 10 mol% of iron(III) oxide photocatalyst (13.1 mg) and tetrahydrofuran (2 ml) were added. The reaction mixture was stirred in a normal open flask under diffuse sunlight until complete consumption of the feedstock was shown by thin layer chromatography (TLC) detection. Upon completion of the reaction, the reaction was quenched with water and filtered to remove the catalyst. The filtrate was concentrated under vacuum. The crude product was purified by column chromatography on silica gel (100-200 mesh) with an eluent of 15:1 ethyl acetate/hexane, resulting in 73.2 mg (95% yield) of pure crystalline 4-trifluoromethoxyphenol.