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90-05-1

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Identification

Name
Guaiacol
CAS
90-05-1
Synonyms
1-HYDROXY-2-METHOXYBENZENE
2-HYDROXYANISOLE
2-METHOXYPHENOL
AKOS BBS-00004261
CATECHOL MONOMETHYL ETHER
EUROLABS G-0120
FEMA 2532
GUAIACOL
GUAIACUL
GUAJACOL
Gulaiacol
O-HYDROXYANISOLE
O-METHOXYPHENOL
O-METHYLCATECHOL
PYROCATECHOL MONOMETHYL ETHER
PYROGUAIAC ACID
1,2-methoxy-Phenol
2-Methoxy phenol (guiacol)
2-methoxy-pheno
2-methoxyphenol (guaiacol)
EINECS(EC#)
201-964-7
Molecular Formula
C7H8O2
MDL Number
MFCD00002185
Molecular Weight
124.14
MOL File
90-05-1.mol

Chemical Properties

Appearance
Light Yellow Oil
mp 
26-29 °C(lit.)

bp 
205 °C(lit.)

density 
1.129 g/mL at 25 °C(lit.)

vapor density 
4.27 (vs air)

vapor pressure 
0.11 mm Hg ( 25 °C)

refractive index 
n20/D 1.543(lit.)

FEMA 
2532
Fp 
180 °F

Stability:
Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Water Solubility 
17 g/L (15 ºC)
FreezingPoint 
28℃
Sensitive 
Air Sensitive
Merck 
14,4553
BRN 
508112
Uses
Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.
CAS DataBase Reference
90-05-1(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System
90-05-1(EPA Substance)

Safety Data

Hazard Codes 
Xn,T,Xi
Risk Statements 
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR 
2810
WGK Germany 
1

RTECS 
SL7525000

Hazard Note 
Toxic/Irritant
HazardClass 
6.1(b)
PackingGroup 
II
HS Code 
29095010
Hazardous Substances Data
90-05-1(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

General Description
Colorless to amber crystals or liquid. Density (of solid) 1.129 g/cm3. Solidifies at 28°C (82.4°F), but may remain liquid for a long time even at a much lower temperature. Slightly water soluble . Soluble in aqueous sodium hydroxide. Used medicinally as an expectorant. Used, because of its anti-oxidant properties, as an anti-skinning agent for paints.
Reactivity Profile
O-METHOXYPHENOL(90-05-1) may react with oxidizing materials. O-METHOXYPHENOL(90-05-1) forms salts readily with bases.
Air & Water Reactions
Sensitive to air and light (darkens). Slightly water soluble.
Hazard
Toxic by ingestion and skin absorption.
Fire Hazard
This chemical is combustible.

Material Safety Data Sheet(MSDS)

Questions And Answer

Chemical properties
It appears as white or slightly yellow crystals or colorless to pale yellow transparent oily liquid. It has a special aromatic smell. It is slightly soluble in water and benzene. It is easily soluble in glycerol. It is miscible with ethanol, ether, chloroform, oil and glacier acetic acid.
Application
Used for pharmaceuticals, dyes and spices intermediates
Mainly used for the preparation of coffee, vanilla, fumigation and tobacco flavor.
Used for the synthesis of dyes, also used as analytical reagents
In medicine, it can be used for the manufacture of calcium guaiacol sulfonate; in the spice industry, it is used the manufacture of vanillin and artificial musk; Used for test copper, hydrocyanic acid and nitrite
Preparative methods
It can be obtained by diazotization and hydrolysis of anthranium anisole.
Obtained from fractionated of wood oil.
In the nature of guaiacol is presented in the guaiacum or pine oil. In the creosote oil obtained from wood dry distillation, guaiacol is the major ingredient. This product could be obtained through fractional distillation of creosote oil. Japan Osaka Refining Company takes o-nitrochlorobenzene as raw material, first synthesizes o-nitroanisole, and then reduces it to o-anisidine, and finally obtains the goods. China's production method is roughly the same. Ingredient consumption quota: 1250 kg / t of amino-containing anisole, 1500 kg / t of sulfuric acid (93%), 700 kg / t of sodium nitrite and 400 kg / t of copper sulfate.
Toxicity
LD50:900 mg / kg (rat, subcutaneous).
LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.

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