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Name Guaiacol
CAS 90-05-1
EINECS(EC#) 201-964-7
Molecular Formula C7H8O2
MDL Number MFCD00002185
Molecular Weight 124.14
MOL File 90-05-1.mol

Chemical Properties

Appearance Light Yellow Oil
Melting point  26-29 °C (lit.)
Boiling point  205 °C (lit.)
density  1.129 g/mL at 25 °C(lit.)
vapor density  4.27 (vs air)
vapor pressure  0.11 mm Hg ( 25 °C)
FEMA  2532
refractive index  n20/D 1.543(lit.)
Fp  180 °F
storage temp.  2-8°C
solubility  H2O: insoluble
form  Liquid After Melting
pka 9.98(at 25℃)
color  Clear colorless to light yellow
Odor at 1.00 % in dipropylene glycol. phenolic smoke spice vanilla woody
PH 5.4 (10g/l, H2O, 20℃)
Stability: Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Odor Threshold 0.0074ppm
Odor Type phenolic
Water Solubility  17 g/L (15 ºC)
FreezingPoint  28℃
Sensitive  Air Sensitive
JECFA Number 713
Merck  14,4553
BRN  508112
Dielectric constant 11.0(-18℃)
LogP 1.34
Guaiacol is a precursor of vanillin and santalidol (a synthetic sandal- wood fragrance). it is obtained from wood tar by the destructive distillation of hardwood, by the distillation of the phenol fraction of coal tar, or through the use of o-dichlorobenzene. it is processed to yield vanillin.
CAS DataBase Reference 90-05-1(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 2-methoxy-(90-05-1)
EPA Substance Registry System 90-05-1(EPA Substance)

Safety Data

Hazard Codes  Xn,T,Xi
Risk Statements 
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR  2810
WGK Germany  1
RTECS  SL7525000
Autoignition Temperature 750 °C
Hazard Note  Toxic/Irritant
HazardClass  6.1(b)
PackingGroup  II
HS Code  29095010
Hazardous Substances Data 90-05-1(Hazardous Substances Data)
LD50 orally in rats: 725 mg/kg (Taylor)
LD50:900 mg / kg (rat, subcutaneous).
LD50: 3.7 mg / kg (rabbit, intravenously).
Oral administration of large amount can stimulate the esophagus and stomach, resulting in heart failure, collapse and death.

Hazard Information

Material Safety Data Sheet(MSDS)

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