367-12-4

Name	2-Fluorophenol
CAS	367-12-4
EINECS(EC#)	206-681-2
Molecular Formula	C6H5FO
MDL Number	MFCD00002155
Molecular Weight	112.1
MOL File	367-12-4.mol

Chemical Properties

Appearance	Clear colourless to yellow liquid
Melting point	16.1 °C (lit.)
Boiling point	171-172 °C/741 mmHg (lit.)
density	1.256 g/mL at 25 °C(lit.)
refractive index	n20/D 1.511(lit.)
Fp	116 °F
storage temp.	Flammables area
solubility	37.7g/l
form	Liquid
pka	8.73(at 25℃)
color	Clear colorless to light yellow-brownish
Specific Gravity	1.256
Stability:	Stable. Flammable. Incompatible with strong oxidizing agents.
Water Solubility	80.72g/L(25 ºC)
BRN	1905112
InChIKey	HFHFGHLXUCOHLN-UHFFFAOYSA-N
CAS DataBase Reference	367-12-4(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 2-fluoro-(367-12-4)
EPA Substance Registry System	367-12-4(EPA Substance)

Safety Data

Hazard Codes	Xn,F,C,Xi,T
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . R10:Flammable. R63:Possible risk of harm to the unborn child. R43:May cause sensitization by skin contact. R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R45:May cause cancer. less more
Safety Statements	S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) . S36/37:Wear suitable protective clothing and gloves . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S16:Keep away from sources of ignition-No smoking . S24/25:Avoid contact with skin and eyes . S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . S53:Avoid exposure-obtain special instruction before use . S36:Wear suitable protective clothing . less more
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	SL4530000
Hazard Note	Flammable/Corrosive
TSCA	T
HazardClass	3
PackingGroup	III
HS Code	29081000

Raw materials And Preparation Products

Hazard Information

General Description

Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g/cm3.

Reactivity Profile

2-FLUOROPHENOL(367-12-4) reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid.

Air & Water Reactions

Highly flammable.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic and irritant.

Chemical Properties

Clear colourless to yellow liquid

Uses

2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria.

Synthesis Reference(s)

Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015

Purification Methods

Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.]

Material Safety Data Sheet(MSDS)

Spectrum Detail

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