ChemicalBook CAS DataBase List 143-74-8

143-74-8

Name	Phenol Red
CAS	143-74-8
EINECS(EC#)	205-609-7
Molecular Formula	C19H14O5S
MDL Number	MFCD00003552
Molecular Weight	354.38
MOL File	143-74-8.mol

Synonyms

3,3-BIS(P-HYDROXYPHENYL)-2,1-3H-BENZOXATHIOLE A-HYDROXY-A A-BIS(P-HYDROXYPHENYL)-O-TOLUENESULFONIC ACID G-SULTONE LABOTEST-BB LT00455865 PHENOL RED PHENOLSULFONEPHTHALEIN PHENOLSULFONPHTHALEIN PHENOLSULFONPHTHALEIN TEST SOLUTION PHENOLSULPHONEPHTHALEIN PHENOSULFOHEPHTHALEIN INDICATOR PHENYLSULFONEPHTHALEIN PHENYLSULFONPHTHALEIN PR SULFONAPHTHAL TIMTEC-BB SBB006473 3,3-bis(p-Hydroxyphenyl)-3H-2,1-benzoxathiol-1,1-dioxide 4,4’-(3h-2,1-benzoxathiol-3-ylidene)bisphenol,s,s-dioxide 4,4’-(3h-2,1-benzoxathiol-3-ylidene)diphenol,s,s-dioxide abcolphenolredf/a fenolipuna Phenol,4,4’-(3H-2,1-benzoxathiol-3-ylidene)bis-,S,S-dioxide

Chemical Properties

Appearance	red-brown powder
Melting point	>300 °C
Boiling point	>300°C
bulk density	200-300kg/m3
density	1.445 Mg m-3
refractive index	1.5300 (estimate)
Fp	>300°C
storage temp.	Store at RT.
solubility	1 M NaOH: soluble1mg/mL
form	Solid
pka	7.9(at 25℃)
color	Red
Odor	Odorless
PH	6.8～8.4
PH Range	6.6(YELLOW)-8.0(RED)
Water Solubility	0.77 g/L
ε(extinction coefficient)	≥10000 at 288-294nm in H2O ≥55000 at 555-561nm in H2O ≥7000 at 357-363nm in H2O
λmax	557nm, 558nm, 360nm, 423nm, 433nm
Merck	14,7247
BRN	326470
Major Application	Display device, sol-gel matrix, photoreceptors, fuel cells, waveguides, paints, detergents, cosmetics, antiperspirant composition, diapers, screening bacteria, detecting viable cells, diagnosis of urogenital ureaplasmosis, treatment of pathogen infections, amyloid-associated diseases, glaucoma, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, erectile dysfunction, Raynaud’s syndrome, heparin overdose, vulvodynia, wound healing, psychoactive drugs, evaluating dental caries activity
Cosmetics Ingredients Functions	BUFFERING
InChI	1S/C19H14O5S/c20-15-9-5-13(6-10-15)19(14-7-11-16(21)12-8-14)17-3-1-2-4-18(17)25(22,23)24-19/h1-12,20-21H
InChIKey	BELBBZDIHDAJOR-UHFFFAOYSA-N
LogP	3.020
CAS DataBase Reference	143-74-8(CAS DataBase Reference)
EPA Substance Registry System	143-74-8(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P304+P340+P312
Hazard Codes	Xi,C
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . R34:Causes burns. less more
Safety Statements	S37/39:Wear suitable gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S27:Take off immediately all contaminated clothing . less more
WGK Germany	3
RTECS	SJ7490000
TSCA	Yes
HS Code	29349990
Storage Class	11 - Combustible Solids
Hazard Classifications	Skin Irrit. 2 STOT SE 3
Toxicity	LD50 orl-rat: >600 mg/kg CTOXAO 4(2),185,71 less more

Raw materials And Preparation Products

Hazard Information

Description

Phenol red belongs to the class of triphenylmethane dyes and is widely used in the textile industry.

Chemical Properties

dark red powder

Uses

As indicator in 0.02-0.05% alcohol solution. pH 6.8 yellow, 8.4 red.

Application

Phenol red solution has been used:
As a tracer dye for microinjection of zebrafish eggs.
As a component of the mMW medium for preparation of mouse embryos.
In the preparation of versene-ethylenediamine tetraacetic acid (EDTA) solution.

Definition

ChEBI: 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney.

Preparation

Phenol red is prepared in Dulbecco′s Phosphate Buffered Saline.

Biochem/physiol Actions

Phenol Red is a pH indicator which changes color from yellow to red.

Safety Profile

Moderately toxic by ingestion and intravenous routes. Mutation data reported. When heated to decomposition it emits toxicvapors of SOx.

Enzyme inhibitor

This pH-indicating dye (FW = 354.38 g/mol; CAS 143-74-8; pKa = 7.9; yellow < pH 6.8; red > pH 8.4), also known as phenolsulfonphthalein and sulfophthalein, is a diagnostic aid for evaluating renal function. A typical stock indicator solution is 0.1 g phenol red in 28.2 mL 10 mM NaOH and 221.8 mL water. Target(s): aldehyde reductase; glutaminase; gglutamyl transpeptidase; glutathione S-transferase; 4- methyleneglutaminase; phosphate uptake; thromboxane A2/prostaglandin H2 receptor; and thyroglobulin iodination.

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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