ChemicalBook CAS DataBase List 80-39-7

80-39-7

Name	N-Ethyl-p-toluenesulfonamide
CAS	80-39-7
EINECS(EC#)	201-275-1
Molecular Formula	C9H13NO2S
MDL Number	MFCD00048511
Molecular Weight	199.27
MOL File	80-39-7.mol

Synonyms

ETSM N-E-PTSA N-ETHYL-P-TOLUENESULFONAMIDE N-Ethyltoluene-4-sulphonamide N-ETHYL-TOLUENESULFONAMIDE Benzenesulfonamide, N-ethyl-4-methyl- Ethyl toluenesulfonamide Ethylp-toluenesulfonamide n-ethyl-4-methyl-benzenesulfonamid n-ethyl-4-methylbenzenesulfonamide N-Ethyl-4-methyl-benzenesulfonamide n-ethyl-4-toluenesulfonamide N-Ethyl-p-methylbenzenesulfonamide N-Ethyl-p-tolylsulfonamide N-Tosylethylamine p-Tolueneethylsulfonamide p-Toluenesulfonamide, N-ethyl- p-Toluenesulfonyl-N-ethylamide Santicizer 3 Unipex 108

Chemical Properties

Appearance	off-white crystalline solid
Melting point	63-65 °C(lit.)
Boiling point	208 °C745 mm Hg(lit.)
density	1.26 g/cm3
refractive index	1.5270 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	11.86±0.50(Predicted)
color	White to Off-White
Stability:	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	FILM FORMING PLASTICISER
InChI	InChI=1S/C9H13NO2S/c1-3-10-13(11,12)9-6-4-8(2)5-7-9/h4-7,10H,3H2,1-2H3
InChIKey	OHPZPBNDOVQJMH-UHFFFAOYSA-N
SMILES	C1(S(NCC)(=O)=O)=CC=C(C)C=C1
LogP	1.960 (est)
Uses	Plasticizer. less more
CAS DataBase Reference	80-39-7(CAS DataBase Reference)
NIST Chemistry Reference	4-Toluenesulfonamide, n-ethyl-(80-39-7)
EPA Substance Registry System	80-39-7(EPA Substance)

Safety Data

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes	Xi
Risk Statements	R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37:Wear suitable protective clothing and gloves . less more
WGK Germany	3
TSCA	Yes
HS Code	29350090
Storage Class	13 - Non Combustible Solids

Raw materials And Preparation Products

Hazard Information

General Description

Platelets (from dilute alcohol or ligroin) or off-white solid.

Reactivity Profile

An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for this chemical are not available; however, N-ETHYL-4-METHYLBENZENE SULFONAMIDE is probably combustible.

Description

N-Ethyl-p-toluenesulfonamide (N-PTSA) is a white crystal commonly used as a pharmaceutical intermediate. It is synthesized by reacting ethyl acetoacetate with p-toluenesulfonyl chloride under alkaline conditions. In the pharmaceutical industry, N-PTSA is utilized in the synthesis of various drugs. The presence of ethyl and p-toluenesulfonamide groups in its structure makes N-PTSA valuable for specific applications in drug synthesis. Additionally, N-PTSA is employed as a plasticiser to enhance polymers more reactivity[1].

Chemical Properties

off-white crystalline solid

References

[1] Xiao Bian . (2025). Solubility, solvent effects and thermodynamic properties of N-Ethyl-p-toluenesulfonamide in twelve pure organic solvents. Journal of the Taiwan Institute of Chemical Engineers, 170, Article 106009. https://doi.org/10.1016/j.jtice.2025.106009

Material Safety Data Sheet(MSDS)

Spectrum Detail

Well-known Reagent Company Product Information

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