Description
2-Methyl-3-biphenylmethanol is a pharmaceutical intermediate and organic chemical synthesis reagent, which can be used in the preparation of drugs such as Bifenthrin and PD-L1 inhibitors, and also in the synthesis of other organic compounds such as 2-methyl-3-phenylphenethylboronic acid pinacol ester, biphenyl-1,2,3-triazole couplings and biphenyl alcohols.
Chemical Properties
white to light yellow crystal powde
Uses
Bifenthrin intermediate.
Application
2-Methyl-3-biphenylmethanol is mainly used in the production of agricultural chemicals bifenthrin and the synthesis material of other pharmaceutical prods.
Hazard
2-Methyl-3-biphenylmethanol causes skin irritation and serious eye irritation. It may cause respiratory irritation.
Synthesis
Carrying out a Suzuki coupling reaction between 3-bromo-2-methylbenzoic acid and phenyl substituted boric acid or phenyl substituted borate to obtain 3-phenyl-2-methylbenzoic acid, and then carrying out a reduction reaction to obtain 2-Methyl-3-biphenylmethanol, wherein the Suzuki coupling reaction is carried out at 10-150 DEG C for 1-12 hours under the action of an alkali. 3-phenyl-2-methylbenzoic acid can be directly reduced with a reducing agent such as borane and lithium aluminium hydride to obtain 2-Methyl-3-biphenylmethanol.
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5857 - 5867
[2] Patent: WO2018/200571, 2018, A1. Location in patent: Page/Page column 44-45
[3] Patent: WO2015/34820, 2015, A1. Location in patent: Page/Page column 42
[4] Patent: US2015/291549, 2015, A1. Location in patent: Paragraph 0210; 0211
[5] Patent: WO2017/118762, 2017, A1. Location in patent: Page/Page column 39; 40
