64706-54-3

Slightly yellow viscous liquid, boiling point 184°C/13.3Pa, 192°C/66.7Pa. N_D²⁰ 1.5538. Bepridil Hydrochloride: C24H34N2O·HCI·H2O. [74764-40-2]. Needle-shaped crystals, melting point 91°C±2°C. Acute toxicity LD50 in mice (mg/kg): 1955 mg/kg oral, 23.5 mg/kg intravenous.

Bepridil is protective against Ebola virus. Bepridil is used in biological study of shortening of electromechnical window in ketamine/xylazine-anesthetized guinea pig model improved QTc interval prolongation and assessed pro-arrhythmic risk during early drug development. Bepridil is also used in therapeutic use in novel high/low solubility classification methods for new molecular entities.

ChEBI: A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.

This substituted pyrrolidine (FWfree-base = 366.55 g/mol) is a calcium channel blocker that inhibits the Na+/Ca2+ exchange, exhibiting antiarrhythmic, antianginal, and vasodilatory properties. Bepridil inhibits the growth of certain brain tumors in vitro. Bepridil also binds to troponin C. Target (s) : Ca2+ channels; ATP-sensitive K+ channels; Na+-activated K+ channels.