Bepridil (74764-40-2) is a clinically useful calcium channel blocker with antianginal activity.1 It has recently been shown to possess potent activity against SARS-CoV-2 in vitro.2 Bepridil was also able to provide protection from Ebola virus3 and other filoviruses in a mouse model4.
antineoplastic, alkylating agent
Bepridil Hydrochloride is a calcium channel blocker. It also activates mitochondrial ATP-sensitive KATP channelsBepridil Hydrochloride is an antiarrhythmic and antihypertensive agent and used for treating atrial fibrillation.
ChEBI: The hydrochloride monohydrate of bepridril.
Bepadin
(Medpointe); Vascor (Johnson & Johnson).
Bepridil hydrochloride,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethylamine hydrochloride (Vascor), is a secondgenerationalkylamine-type channel blocker, structurallyunrelated to the dihydropyridines. Its actions are less specificthan those of the three prototypical channel blockers,verapamil, diltiazem, and nifedipine. In addition to being aCa2+ channel blocker, it inhibits sodium flow into the hearttissue and lengthens cardiac repolarization, causing bradycardia.Caution should be used if it is given to a patient withhypokalemia. Bepridil hydrochloride is used for stableangina. The drug has a half-life of 33 hours and is highlybound to protein (99%).
Moderately toxic by ingestion.
Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na+-Ca2+ exchange; inhibits growth of brain tumor cells in vitro.
In addition to class IV effects, bepridil also
shows class I effects. The substance is active
against both supraventricular and ventricular arrhythmias
, .
[1] L M HOLLINGSHEAD A F D Faulds. Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris.[J]. Drugs, 1992, 44 5: 835-857. DOI:
10.2165/00003495-199244050-00009[2] EROL C VATANSEVER. Bepridil is potent against SARS-CoV-2 in vitro.[J]. ACS Catalysis , 2021. DOI:
10.1073/pnas.2012201118[3] LISA M. JOHANSEN. A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity[J]. Science Translational Medicine, 2015, 7 290. DOI:
10.1126/scitranslmed.aaa5597[4] LISA EVANS DEWALD. The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.[J]. Journal of Infectious Diseases, 2018, 218 suppl_5: S588-S591. DOI:
10.1093/infdis/jiy332
