Chemical Properties
Off-White Solid
Uses
A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
Uses
A nonsteroidal anti-inflammatory with local anesthetic properties.
Description
Benzydamine hydrochloride is a non-steroidal antiinflammatory
drug used both topically and systemically.
It has been reported as a sensitizer and a
photosensitizer and caused occupational contact dermatitis
in a nurse.
Originator
Tantum,Angelini
Definition
ChEBI:Benzydamine hydrochloride is a member of indazoles.
Manufacturing Process
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120
ml of concentrated hydrochloric acid at 25°C was added concentrated solution
of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in
1.5 L of water. To this solution under nitrogen was added 400 g of sodium
bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The
obtained solid product was dissolved in water and then to the solution was
added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)
propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
Brand name
Tantum (Angelini Francesco, Italy).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Side effects
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
