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• Synthesis

  

  Report 1,

  2,3-Butanedione (10 g; 116 mmol) and 20 mL CHCl3 were added to a 250 mL round-bottom flask equipped with a reflux condenser and a dropping funnel. Bromine (37 g, 12 mL, 232 mmol, d: 3.1028 g/mL) was dissolved in 25 mL CHCl3 and slowly added dropwise to the reaction mixture. The reaction was carried out at 50 °C until no HBr precipitated. The crude mixture was cooled overnight in a refrigerator. The precipitate was filtered off.

  1,4-Dibromo-2,3-butanedione was obtained by recrystallization of the crude product from CHCl3.

  Report II

  A solution of 2,3-butanedione (5.000 g, 58.0 mmol) in 10 mL of CHCl3 was slowly added dropwise to a solution of bromine (18.560 g, 116.0 mmol) in 6 mL of CHCl3 at room temperature. After the addition was complete, the reaction was carried out at 48 °C for 3 hours. The mixture was cooled in an ice bath for 2 hours, and the precipitate was filtered and purified by recrystallization from CHCl3 to obtain a yellow solid of 1,4-dibromo-2,3-butanedione. Yield: 9.112 g (65%). Melting point: 116-117 °C.

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• Application

  1,4-Dibromo-2,3-Butanedione is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.;

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