ChemicalBook CAS DataBase List 615-65-6

615-65-6

Name	2-Chloro-4-methylaniline
CAS	615-65-6
EINECS(EC#)	210-440-7
Molecular Formula	C7H8ClN
MDL Number	MFCD00007666
Molecular Weight	141.6
MOL File	615-65-6.mol

Synonyms

1-AMINO-2-CHLORO-4-METHYLBENZENE 2-CHLORO-4-METHYLANILINE 2-CHLORO-4-TOLUIDINE 2-CHLORO-P-TOLUIDINE 3-CHLORO-4-AMINOTOLUENE 4-AMINO-3-CHLOROTOLUENE 2-Chlor-4-toluidin 2-chlor-4-toluidin(czech) 2-Chloro-4-methylbenzamine 2-chloro-4-methyl-benzenamin 2-Chloro-4-Methyl-Benzenamine 2-chloro-p-toluidin 4-Methyl-2-chloroaniline p-Toluidine, 2-chloro- ORTHO CHLORO PARA TOLUIDINE 2-CHLORO-PARA-TOLUIDINE 2-chlor-4-toluidine 2-CHLORO-4-METHYLANILINE/4-AMINO-3-CHLOROTOLUENE 2-Chloro-p-toluidine, 4-Amino-3-chlorotoluene 2-Chloro-4-methylaniline ,98%

Chemical Properties

Appearance	The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.
Melting point	7 °C (lit.)
Boiling point	223-225 °C (lit.)
density	1.151 g/mL at 25 °C(lit.)
refractive index	n20/D 1.575(lit.)
Fp	211 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	methanol: soluble
form	Liquid
pka	3.09±0.10(Predicted)
color	Clear yellow to pale brown
Detection Methods	GC
BRN	774514
Stability:	Acid Sensitive, Light Sensitive
InChI	1S/C7H8ClN/c1-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3
InChIKey	XGYLSRFSXKAYCR-UHFFFAOYSA-N
SMILES	Cc1ccc(N)c(Cl)c1
CAS DataBase Reference	615-65-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2-chloro-4-methyl-(615-65-6)
EPA Substance Registry System	615-65-6(EPA Substance)

Safety Data

Hazard Codes	Xn
Risk Statements	R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . R22:Harmful if swallowed. R33:Danger of cumulative effects. less more
Safety Statements	S36/37:Wear suitable protective clothing and gloves . S37/39:Wear suitable gloves and eye/face protection . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . less more
RIDADR	UN 3429 6.1/PG 3
WGK Germany	3
RTECS	XU5110000
F	8-9-23
Hazard Note	Harmful
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29214200
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Skin Irrit. 2
Safety Profile	Poison by ingestion. A severe eye and skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also other chloro toluidine entries. less more
Hazardous Substances Data	615-65-6(Hazardous Substances Data)

Raw materials And Preparation Products

Hazard Information

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

Chemical Properties

clear yellow to pale brown liquid

Chemical Properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

Uses

2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry.

Uses

2-Chloro-4-methylaniline is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.

Synthesis

The substrate 3-chloro-4-nitrotoluene was dissolved in MeOH (HPLC grade, 0.1 M). At room temperature in the presence of 0.5 mol% SiliaCat Hydrogenation was carried out in the presence of Pd0. The resulting mixture was degassed twice, replacing the vacuum

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615-65-6

Chemical Properties

Safety Data

Raw materials And Preparation Products

Preparation Products

Hazard Information

Potential Exposure

First aid

Shipping

Incompatibilities

Chemical Properties

Chemical Properties

Uses

Uses

Synthesis

Material Safety Data Sheet(MSDS)

Questions And Answer

Description

Spectrum Detail

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