Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Material Safety Data Sheet(MSDS) Hazard Information Spectrum Detail Well-known Reagent Company Product Information
WebSite >  CAS DataBase List  > 100-61-8

100-61-8

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Material Safety Data Sheet(MSDS) Hazard Information Spectrum Detail Well-known Reagent Company Product Information

Product Image

Identification

Name
N-Methylaniline
CAS
100-61-8
Synonyms
ANILINOMETHANE
LABOTEST-BB LTBB000436
MONOMETHYLANILINE
N-METHYLAMINOBENZENE
N-METHYLANILINE
N-MONOMETHYLANILINE
(Methylamino)benzene
Benzenamine, N-methyl-
Benzenenamine, N-methyl-
methylaniline(non-specificname)
methylaniline-n
Methylphenylamine
n’-BIcthylanilin
n-methyl-anilin
N-Methylanilinium ion
n-methyl-benzenamin
N-Methylbenzenamine
N-methyl-Benzenamine
n-methyl-benzeneamin
n-methylbenzeneamine
EINECS(EC#)
202-870-9
Molecular Formula
C7H9N
MDL Number
MFCD00008283
Molecular Weight
107.15
MOL File
100-61-8.mol

Chemical Properties

Appearance
colourless to pale yellow liquid
Appearance
N-Methylaniline is a yellow to light brown oily liquid with a weak, ammonia-like odor. Turns reddishbrown if left standing. The odor threshold is 1.7 ppm
mp 
−57 °C(lit.)

Melting point 
-57 °C (lit.)
Boiling point 
196 °C (lit.)
bp 
196 °C(lit.)

density 
0.989 g/mL at 25 °C(lit.)

vapor pressure 
0.5 hPa (20 °C)
refractive index 
n20/D 1.571(lit.)

Fp 
174 °F

storage temp. 
Store below +30°C.
solubility 
water: slightly soluble30g/L
pka
4.84(at 25℃)
form 
Liquid
color 
Clear yellow to brown
Stability:
Stability Combustible. Incompatible with strong oxidizing agents. Discolours upon exposure to air.
Odor
Moderate aniline-type.
PH
7.6 (1g/l, H2O, 20℃)
Water Solubility 
30 g/L
Sensitive 
Air Sensitive
Merck 
14,6019
BRN 
741982
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.19 at 25 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits
NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 2 ppm (9 mg/m3); ACGIH TLV: TWA 0.5 ppm (adopted).
InChIKey
AFBPFSWMIHJQDM-UHFFFAOYSA-N
Uses
Organic synthesis, solvent, acid acceptor.
CAS DataBase Reference
100-61-8(CAS DataBase Reference)
NIST Chemistry Reference
Aniline, N-methyl-(100-61-8)
EPA Substance Registry System
100-61-8(EPA Substance)

Safety Data

Hazard Codes 
T,N
Risk Statements 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
Safety Statements 
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
RIDADR 
UN 2294 6.1/PG 3

WGK Germany 
3

RTECS 
BY4550000


8
Autoignition Temperature
500 °C
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
Safety Profile
Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
Hazardous Substances Data
100-61-8(Hazardous Substances Data)
Toxicity
LD in rabbits (g/kg): 0.28 orally; in rabbits, cats (mg/kg): 24, 24 i.v. (Treon)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Hazard Information

Hazard
Toxic by ingestion, inhalation, and skin absorption. Methemoglobinemia and central nervous system impairment.
Potential Exposure
The material is used as an intermediate in organic synthesis, as a solvent and as an acid acceptor
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Shipping
UN2294 N-Methylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Chemical Properties
N-Methylaniline is a yellow to light brown oily liquid with a weak, ammonia-like odor. Turns reddishbrown if left standing. The odor threshold is 1.7 ppm
Waste Disposal
Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.
Physical properties
Colorless to yellow to pale brown liquid with a faint, ammonia-like odor. Odor threshold concentration is 1.7 ppm (quoted, Amoore and Hautala, 1983).
Definition
ChEBI: A methylaniline that is aniline carrying a methyl substituent at the nitrogen atom.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 14, p. 1007, 1966 DOI: 10.1248/cpb.14.1007
Journal of the American Chemical Society, 107, p. 493, 1985 DOI: 10.1021/ja00288a037
Synthetic Communications, 13, p. 601, 1983 DOI: 10.1080/00397918308059535
Health Hazard
Recommended Personal Protective Equipment: Approved respirator; rubber gloves; splash proof goggles; Symptoms Following Exposure: Inhalation causes dizziness and headache. Ingestion causes bluish discoloration (cyanosis) of lips, ear lobes, and fingernail beds. Liquid irritates eyes. Absorption through skin produces same symptoms as for ingestion; General Treatment for Exposure: INHALATION: remove victim to fresh air and call a physician at once; administer oxygen until physician arrives. INGESTION: give large amount of water; get medical attention at once. EYES or SKIN: flush with plenty of water for at least 15 min.; if cyanosis is present, shower with soap and warm water, with special attention to scalp and finger nails; remove any contaminated clothing; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Inhalation Limits: Data not available; Toxicity by Ingestion: Data not available; Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Data not available; Liquid or Solid Irritant Characteristics: Data not available; Odor Threshold: Data not available.
Chemical Reactivity
Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastic; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Carcinogenicity
N-methyl aniline (1.95 g/kg of food) given together with sodium nitrite (1.0 g/l of drinking water) to Swiss mice resulted in a 17% incidence of lung adenomas and a 14% incidence of malignant lymphomas; there were no carcinogenic effects in animals treated with Nmethyl aniline alone, suggesting that in vivo nitrosation is necessary for forming carcinogenic nitrosamines.
In bacterial mutagenicity assays N-methyl aniline was negative with or without metabolic activation.
Environmental Fate
Soil. Reacts slowly with humic acids or humates forming quinoidal structures (Parris, 1980).
Purification Methods
Dry it with KOH pellets and fractionally distil it under vacuum. Acetylate, and the acetyl derivative is recrystallised to constant melting point (m 101-102o), then hydrolysed with aqueous HCl and distilled from zinc dust under reduced pressure. [Hammond & Parks J Am Chem Soc 77 340 1955, Beilstein 12 IV 241.]

Spectrum Detail

Well-known Reagent Company Product Information

SupplierMore