58691-88-6

Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency.

Theramex (Monaco)

A progestogen, derivatives of which are used in contraceptives and hormone therapies.

Progetin used in implantable hormone replacement therapies.

ChEBI: Nomegestrol is a corticosteroid hormone.

LUTENYL

Nomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate.

[1] J BOTELLA. Structure-activity and structure-affinity relationships of 19-nor-progesterone derivatives in rat uterus.[J]. Journal of Endocrinological Investigation, 1990, 13 11: 905-910. DOI: 10.1007/bf03349652