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50700-72-6

Supplier Related Products Identification Chemical Properties Safety Data Raw materials And Preparation Products Material Safety Data Sheet(MSDS) Questions And Answer Hazard Information

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Identification

Name
Vecuronium bromide
CAS
50700-72-6
Synonyms
(+)-1-(3,17-diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide
norcuron
VECRONIUM BROMIDE
VECURONIUM BROMIDE
1-(3-alpha,17-beta-diacetoxy-2-beta-piperidino-5-alpha-androstan-piperidiniu
17beta-diol,16beta-pipecolinio-2beta-piperidino-5alpha-androstan-3alphbro
mide,diacetate
nc-45
orgnc45
vecuronium
VECURONIUM BROMIDE, USP STANDARD
VECURONIUM BROMIDE, RELATED COMPOUND A3ALPHA, 17BETA-DIACETYL-OXY-2BETA, 16BETA-BISPIPERIDINYL-5ALPHA-ANDROSTAN USP STANDARD
VECURONIUM BROMIDE, EP
VECUROMIUM BROMIDE
VECURUNIUM BROMIDE
Musculax
Piperidinium, 1-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (9CI)
Piperidinium, 1-[(2,3α,5α ,16,17)-3,17-bis(acetyloxy)-2-(1-piperidinyl )androstan-16-yl]-1-methyl-, bromide
(+)-1-(3,17-Diacetoxy-2-piperidino-5-androstan-16-yl)-1-methylpiperidinium bromide
VENCURONIUM BROMIDE
EINECS(EC#)
256-723-9
Molecular Formula
C34H57BrN2O4
MDL Number
MFCD00867762
Molecular Weight
637.73
MOL File
50700-72-6.mol

Chemical Properties

Melting point 
227-229°C
mp 
227-229°C
alpha 
+30.5~+35.0゜(D/20℃)(c=0.5,dil.HCl)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol.
form 
neat
Merck 
14,9941
BRN 
4837308
InChIKey
VEPSYABRBFXYIB-PWXDFCLTSA-M
CAS DataBase Reference
50700-72-6(CAS DataBase Reference)

Safety Data

Hazard Codes 
Xi
Risk Statements 
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
WGK Germany 
3
RTECS 
TN4875000
HS Code 
2933399090
Toxicity
LD50 in mice: 0.061 mg/kg i.v. (Buckett)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

Questions And Answer

Description
Vecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation.
References
https://en.wikipedia.org/wiki/Vecuronium_bromide
https://www.drugbank.ca/drugs/DB01339  

Hazard Information

Chemical Properties
White Solid
Uses
alcohol antagonist
Uses
An aminosteroid, competitive neuromuscular blocker agent.
Definition
ChEBI: The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium su stituents.
Brand name
Norcuron (Organon).
Biological Functions
Vecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion.
General Description
Vecuronium bromide, 1-(3 ,17 -dihydroxy-2 -piperidino-5 -androstan-16 -yl)-1-methylpiperidinium bromide diacetate (Norcuron), is themonoquaternary analog of pancuronium bromide. It belongsto the class of nondepolarizing neuromuscular blockingagents and produces effects similar to those of drugs in thisclass. It is unstable in the presence of acids and undergoesgradual hydrolysis of its ester functions in aqueous solution.Aqueous solutions have a pH of about 4.0.
Clinical Use
Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.
Veterinary Drugs and Treatments
Vecuronium is indicated as an adjunct to general anesthesia to produce muscle relaxation during surgical procedures or mechanical ventilation and to facilitate endotracheal intubation. It causes very minimal cardiac effects and generally does not cause the release of histamine.
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