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68-22-4

Name Norethindrone
CAS 68-22-4
EINECS(EC#) 200-681-6
Molecular Formula C20H26O2
MDL Number MFCD00067596
Molecular Weight 298.42
MOL File 68-22-4.mol

Chemical Properties

Appearance Off-White to Pale Yellow Solid
Melting point  205-206 °C (lit.)
alpha  D20 -31.7° (chloroform); D20 -25° (chloroform)
Boiling point  379.83°C (rough estimate)
density  1.0766 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  2-8°C
solubility  chloroform: ≥50 mg/mL, clear, colorless
form  powder
pka 13.09±0.40(Predicted)
color  white to off-white
Water Solubility  7.043mg/L(25 ºC)
Usage Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen
Merck  6697
BRN  1915671
BCS Class 1
InChIKey VIKNJXKGJWUCNN-XGXHKTLJSA-N
CAS DataBase Reference 68-22-4(CAS DataBase Reference)
NIST Chemistry Reference Norethindrone(68-22-4)
EPA Substance Registry System 68-22-4(EPA Substance)

Safety Data

Hazard Codes  Xn
Risk Statements 
R40:Limited evidence of a carcinogenic effect.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  RC8975000
HS Code  29144000
Safety Profile
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Mddly toxic by ingestion. Human systemic effects by ingestion: dermatitis and androgenic effects. Human teratogenic effects: developmental abnormalities of the musculoskeletal system and urogenital system; and behavioral effects in the newborn. Human reproductive effects: spermatogenesis; testes, epididymis, sperm duct changes; impotence; male breast development; other male effects; ovaries, fallopian tube changes; menstrual cycle effects; postpartum effects; changes in female fertility. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazardous Substances Data 68-22-4(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 6gm/kg

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