ChemicalBook CAS DataBase List 72-63-9

72-63-9

Name	Metandienone
CAS	72-63-9
EINECS(EC#)	200-787-2
Molecular Formula	C20H28O2
MDL Number	29372900
Molecular Weight	300.435
MOL File	72-63-9.mol

Synonyms

1,2-Dehydro-17-methyltestosterone 17-alpha-methyl-17-beta-hydroxy-1,4-androstadien-3-one 17alpha-methyl-17beta-hydroxyandrosta-1,4-dien-3-one 17alpha-Methyl-1-dehydrotestosterone 17beta-Hydroxy-17alpha-methylandrosta-1,4-dien-3-one 17-beta-hydroxy-17-alpha-methyl-androsta-4-dien-3-one 17-beta-Hydroxy-17-alpha-methylandrostra-1,4-dien-3-one 17-beta-hydroxy-17-methyl-androsta-4-dien-3-one 17beta-hydroxy-17-methyl-androsta-4-dien-3-one 17-hydroxy-17-methyl-4-dien-3-on(17-beta)-androsta- 17-hydroxy-17-methyl-4-dien-3-on(17beta)-androsta- 17-Hydroxy-17-methylandrosta-1,4-dien-3-one 17-Methyl-17-hydroxy-1,4-androstadi-en-3-one 1-Dehydro-17-methyltestosterone a1-dehydromethyltesterone Abirol Anabolicum Medivet Anabolin Andoredan Androsta-1,4-dien-3-one, 17beta-hydroxy-17alpha-methyl-

Chemical Properties

Melting point	165-166 °C
Boiling point	381.66°C (rough estimate)
density	1.0597 (rough estimate)
refractive index	1.4800 (estimate)
Fp	-2℃
storage temp.	2-8°C
solubility	Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form	neat
pka	15.12±0.60(Predicted)
Optical Rotation	[α]1.15/D 0.5±0.5° in chloroform
Merck	5951
BRN	2056255
InChI	InChI=1/C20H28O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h6,9,12,15-17,22H,4-5,7-8,10-11H2,1-3H3/t15-,16+,17+,18+,19+,20+/s3
InChIKey	XWALNWXLMVGSFR-HLXURNFRSA-N
SMILES	[C@]12(CCC3=CC(=O)C=C[C@]3(C)[C@]1(CC[C@]1(C)[C@](O)(C)CC[C@@]21[H])[H])[H] \|&1:0,9,11,14,16,21,r\|
CAS DataBase Reference	72-63-9(CAS DataBase Reference)
NIST Chemistry Reference	Methandrostenolone(72-63-9)

Safety Data

Symbol(GHS)	GHS02,GHS07,GHS08
Signal word	Danger
Hazard statements	H225-H332-H360FD
Precautionary statements	P201-P210-P280-P308+P313-P370+P378-P403+P235
Hazard Codes	F,T
Risk Statements	60-61-11-19-38 less more
Safety Statements	53-45 less more
RIDADR	3249
WGK Germany	3
RTECS	BV8000000
F	8
HazardClass	6.1(b)
PackingGroup	III
HS Code	29329970
Hazardous Substances Data	72-63-9(Hazardous Substances Data)
Toxicity	LD50 oral in rat: > 1gm/kg less more
DEA Controlled Substances	CSCN: 4000 CSA SCH: Schedule III NARC: No

Hazard Information

Chemical Properties

White Solid

Originator

Dianabol,Ciba,US,1960

Uses

Anabolic steroid. Androgen. Controlled substance.

Definition

ChEBI: Methandrostenolone is an organic molecular entity.

Manufacturing Process

As described in US Patent 2,929,763, methandrostenolone may be made by a fermentation route. 2 g of sodium nitrate, 1 g of primary potassium orthophosphate, 0.5 g of magnesium sulfate heptahydrate, 0.5 g of potassium chloride, 50 g of glucose and 1 g of Difco yeast extract are dissolved in one liter of tap water, brought to pH 5 by addition of a sodium hydroxide solution and sterilized. The resulting nutrient solution is inoculated with 50 cc of a 4- day-old shaking culture of Didymella lycopersici and shaken for 48 hours at 27°C, whereby the culture becomes well developed.
To two liters of a culture so prepared there is added under sterile conditions a solution of 500 mg of 17α-methyl-testosterone in 15 cc of acetone. Shaking is carried out for 3 days at 27°C, the mycellium then filtered off with suction, washed with water and ethyl acetate and the combined filtrates extracted with ethyl acetate. The extraction residue obtained after evaporation of the solvent is dissolved in a little acetone. On addition of ether, the 1-dehydro-17αmethyl-testosterone is obtained in compact crystals. MP 163° to 164°C.
An alternative synthetic route is described in US Patent 2,900,398 as follows. A suspension of 30 g of 17α-methyl-testosterone and 10 g of selenium dioxide in 600 cc of tertiary amyl alcohol is treated with 60 g of magnesium powder and 6 cc of glacial acetic acid.
The mixture is refluxed for 24 hours with good stirring in an atmosphere of nitrogen, another 10 g of selenium dioxide being added after 10 hours. After some cooling, the suspension is filtered through some Hyflo and washed thoroughly with ethyl acetate. The resulting brown solution is evaporated in vacuo and the residue dissolved in ethyl acetate.
The ethyl acetate solution is then washed with water, dried and evaporated. To remove any selenium still present, the residue is dissolved in 200 cc of methanol and mixed with 100 g of iron powder and 2 g of active carbon. The mixture is heated for 30 minutes with stirring under reflux, then filtered with suction, washed with methanol and the solution evaporated in vacuo. The residue is then chromatographed on 900 g of aluminum oxide. The residues of the evaporated benzene and ether fractions are treated with active carbon in methanol or acetone, evaporated again, and the residue recrystallized from a mixture of acetone and ether. There are obtained 17.5 g of pure 1-dehydro17α-methyl-testosterone which melts at 163° to 164°C.

Therapeutic Function

Androgen, Anabolic

Material Safety Data Sheet(MSDS)

Questions And Answer

Preparation

Metandienone is prepared from sisal saponins.
;
Indications and Usage
Metandienone is a dehydrogenation derivative of methyltestosterone. Its protein assimilating effects are similar to those of testosterone propionate, but its androgen effects are slightly weaker and are about 1/100 those of the latter. This drug can promote protein synthesis, inhibit protein heterogeneity, maintain a positive nitrogen balance, improve appetite, aid muscle growth, and encourage weight gain. It can cause calcium and phosphorous deposition in bone tissue, promote bone mesenchymal cell formation, and increase bone calcification and growth. It can encourage tissue generation and granulation and speed up healing of wounds. It lowers blood cholesterol and improves fat metabolism.
Metandienone is an androgen and anabolic hormone drug. It is suitable for people with insufficient protein synthesis and increased protein decomposition, such as patients with negative nitrogen balance caused by chronic wasting diseases, severe infections, trauma, and burns, as well as malignant tumors, osteoporosis, stunted children, dwarfism, fractures, less healing, and high cholesterol. ;
Drug Interactions
When Metandienone is used with oxyphenbutazone, the blood concentration of oxyphenbutazone may increase. ;
Adverse reactions
1. Metandienone’s adverse are identical to those of regular androgen and anabolic steroids. There may be nausea, vomiting, indigestion, diarrhea, and other digestive tract reactions. Long term, high dosage use may lead to bone weight, water-sodium retention, increased blood supply to skin, hypocalcemia, hyperosteogeny, etc. Women may experience slight virilism, with effects including acne, hirsuitism, lowered voice, clitoral hypertrophy, irregular menstruation, etc. 2. Metandienone’s side effects on the liver include jaundice and liver failure. There have been reports of liver cancer and benign hepatocellular adenoma tied to Metandianone use. ;
Contradictions
1. Do not use this drug if allergic.
2. Do not use if experiencing liver failure.
3. Do not use during pregnancy or if pregnancy may occur during treatment.
4. Do not use if experiencing prostate cancer, kidney disease, hypertension, or prostate hypertrophy. ;
Warnings and Precautions
1. Monitor liver functions while using Metandienone.
2. Dosage for elderly patients should be reduced accordingly.
3. Consume appropriate amounts of protein, sugar and vitamins during treatment to improve efficacy. ;

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72-63-9

Chemical Properties

Safety Data

Hazard Information

Chemical Properties

Originator

Uses

Definition

Manufacturing Process

Therapeutic Function

Material Safety Data Sheet(MSDS)

Questions And Answer

Preparation

Indications and Usage

Drug Interactions

Adverse reactions

Contradictions

Warnings and Precautions

Well-known Reagent Company Product Information

Supplier

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