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56-34-8

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Identification

Name
Tetraethyl ammonium chloride
CAS
56-34-8
Synonyms
ETAMON CHLORIDE
TEA
TEA CHLORIDE
TETRAETHYLAMMONIUM CHLORIDE
Ethanaminium,N,N,N-triethyl-,chloride
n,n,n-triethyl-ethanaminiuchloride
n,n,n-triethylethanaminiumchloride
teac
tetraethyl-ammoniuchloride
Tetraethylammonium choride
TETRAETHYLAMMONIUM CHLORIDE SOLUTION
TETRAETHYLAMMONIUM CHLORIDE, FOR MOLECUL AR BIOLOGY
TETRAETHYLAMMONIUM CHLORIDE, ELECTRO-CHE MICAL GRADE
TETRAETHYLAMMONIUM CHLORIDE NICOTINIC BL OCKING AG
Tetraethylammonium
TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT
AMMONIUM,TETRAETHYL-,CHLORIDE
TETRAETHYLAMINEHYDROCHLORIDE
Tetraethylammonium chloride monohydrate, 99+%
Tetraethylammonium chloride ,98%
EINECS(EC#)
200-267-5
Molecular Formula
C8H20ClN
MDL Number
MFCD00011828
Molecular Weight
165.7
MOL File
56-34-8.mol

Chemical Properties

Appearance
white crystalline powder
Melting point 
39°C
mp 
39°C
Boiling point 
273.32°C (rough estimate)
density 
1.08
refractive index 
1.5480 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear, colorless

form 
Crystalline Powder
color 
white to light yellow

Stability:
Stable. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility 
Soluble in water, ethanol, chloroform, or acetone
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03
Detection Methods
T,NMR
Merck 
9200
BRN 
3563247
InChIKey
YMBCJWGVCUEGHA-UHFFFAOYSA-M
Uses
Medicine (nerve-blocking agent).
CAS DataBase Reference
56-34-8(CAS DataBase Reference)
EPA Substance Registry System
56-34-8(EPA Substance)

Safety Data

Hazard Codes 
Xn,Xi
Risk Statements 
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
WGK Germany 
3

RTECS 
BS6125000


3-10
TSCA 
Yes
HS Code 
29239000
Toxicity
LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

msds information
TEA chloride(56-34-8).msds

Hazard Information

Chemical Properties
white crystalline powder
Definition
ChEBI: A quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen.
General Description
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Biological Activity
Non-selective K + channel blocker.
Biochem/physiol Actions
Tetraethylammonium chloride (TEAC) blocks K+ channels non-specifically. In rat aorta rings, tetraethylammonium inhibits relaxation induced by peroxynitrite. It blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents. TEAC can increase the contractility and mobility of colon and rectum and is a therapeutic option for Hirschsprung′s disease patients. TEAC reduces the inflammatory responses, improves cardiac, vascular and hemodynamic properties during early sepsis in animals. TEAC has cytotoxic and anti-proliferative potential and induces apoptosis in glioma cells by downregulating B-cell lymphoma-2 (Bcl-2) and upregulating Bcl-2 associated X (Bax).
Purification Methods
Crystallise the chloride from EtOH by adding diethyl ether, from warm water by adding EtOH and diethyl ether, from dimethylacetamide or from CH2Cl2 by addition of diethyl ether. Dry it over P2O5 in vacuum for several days. It also crystallises from acetone/CH2Cl2/hexane (2:2:1) [Blau & Espenson J Am Chem Soc 108 1962 1986, White & Murray J Am Chem Soc 109 2576 1987]. [Beilstein 4 IV 332.]

Spectrum Detail

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